糖尿病肾病患者血清CC趋化因子升高并与AGE-肽相关-东南大学学报医学版

糖尿病肾病患者血清CC趋化因子升高并与AGE-肽相关

作者：孙子林¹ 金晖² 李世云² 弓玉祥³ 李丽⁴ 张林⁵ 刘必成³ 刘乃丰⁵ 戴德哉⁶

单位：1.中国药科大学,药理学研究室,江苏,南京,210009;东南大学附属中大医院,内分泌科,江苏,南京,210009； 2.东南大学附属中大医院,内分泌科,江苏,南京,210009； 3.东南大学,肾脏病研究所,江苏,南京,210009； 4.东南大学附属中大医院,临床免疫科,江苏,南京,210009； 5.东南大学,心

关键词：趋化因子单核细胞趋化蛋白-1 受活化调节由正常T细胞表达分泌的趋化蛋白糖基化终产物-肽糖尿病肾病

分类号：R587.2

出版年·卷·期（页码）：2005·24·第六期（385-389）

摘要：

目的:观察糖尿病肾病(DN)患者血清单核细胞趋化蛋白-1(MCP-1)和受活化调节、由正常T细胞表达分泌的趋化蛋白(RANTES)水平,并探讨它们与糖基化终产物-肽(AGE-P)的相互关系.方法:设健康对照(NC)组46例,糖尿病(DM)患者176例分为正常蛋白尿(DM N)组、微量白蛋白尿(DM Mi)组及显性蛋白尿(DM Ma)组.流动注射分析法检测血清AGE-P,ELISA法检测血清MCP-1和RANTES.结果:(1)DM患者血清MCP-1、RANTES和AGE-P水平均明显高于NC组(均为P＜0.01);(2)DM Ma组和DM Mi组血清MCP-1水平均显著高于DM N组(均为P＜0.05);(3)DM Ma组血清AGE-P水平明显高于DM Mi组和DM N组(P＜0.05和P＜0.01);(4)DN患者血清AGE-P与RANFES及MCP-1水平之间呈正相关(r=0.31,P＜0.05;r=0.53,P＜0.001).结论:DM患者血清AGE-P、RANTES和MCP-1水平升高;血清AGE-P及MCP-1水平与DN病变程度平行,DN患者血清AGE-P与RANTES及MCp1呈正相关.

Objective To investigate the serum level of MCP?1 and RANTES in patients with diabetic nephropathy(DN) and explore the relationship between advanced glycosylation end products-peptide(AGE?P) and these two chemokines.Methods 46 healthy people and 176 diabetic patients(DM) were included in the study.Serum AGE?P?was?measured?by?using

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