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肝癌的基因免疫治疗若干研究
作者:房良华 姜藻 
单位:东南大学,临床医学院,江苏,南京,210009
关键词:基因疗法 过继免疫疗法 肿瘤疫苗 肝肿瘤 综述 
分类号:R735.7, R457.2
出版年·卷·期(页码):2005·24·第五期(351-354)
摘要:

肝癌的发生发展与机体的免疫功能状态和某些基因的异常有关.通过激发机体的主动免疫功能和过继产生被动免疫的基因免疫治疗成为肝癌辅助治疗的热点.现综述近年来基因免疫治疗肝癌的若干进展.

The developoment and progression of liver neoplasms is related to the immunological status of body and gene abnormality.Gene-immunological therapy becomes a popular method in the auxiliary therapy of the liver neoplasms by exciting initiative and adoptive immunity.This review summarises the advances of gene-immunological therapy for the liver neoplasms.

参考文献:

[1] YOU T G, WANG H S, YANG J H. Transfection of IL-2 and/or IL-12 genes into spleen in treatment of rat liver cancer. World J Gastroenterology2004(15)
[2] KUSHIDA S, PENG B G, UCHIMURA E. A tumour vaccine of fixed tumour fragments in a controlled-release vehicle with cytokines for therapy of hepatoma in mice, 2004(7)
[3] ITOKAWA Y, MAZDA O, UEDA Y. Interleukin-12 genetic administration suppressed metastatic liver tumor unsusceptible to CTL. 2004(4). doi:10.1016/j.bbrc.2003.12.200
[4] JAIN A, SLANSKY J E, MATEY L C. Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases. 2003
[5] MATSUI M, MSCHIDA S, ITANI-YOHDA T. Downregulation of the proteasome submits,transporter and antigen presentation in hipatocellular carcinoma,and their restoration by in terferon-gamma, 2002(8)
[6] CHOI E A, LEI H, MARON D J. Combined 5-fluorouracil/systemic interferon-beta gene therapy results in long-term survival in mice with established colorectal liver metastases. 2004(4). doi:10.1158/1078-0432.CCR-0040-03
[7] YOON S K, KIM T G, CHO H I. Suppression of tumor formation and indution of natural killer cell activity in BALB/c nude mice by human B7-1(CD80) gene transfer subcutaneously injected with human hepatocellular carcinoma cells(Huh-7), 2003
[8] GE N L, YE S L, ZHENG N. Prevention of hepatocellular carcinoma in mice by IL-2 and B7-1 genes co-transfected liver cancer cell vaccines. World J Gastroenterology2003(10)
[9] PAN P Y, LI Y, LI Q. In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery. 2004(1)
[10] BRISTOL J A, ZHU M, JI H. In vitro and in vivo activities of an oncolytic adenoviral vector designed to express GM-CSF. 2003(6)
[11] IRIE M, HOMMA S, KOMITA H. Inhibition of spontaneous development of liver tumors by inoculation with dendritic cells loaded with hepatocellular carcinoma cells in C3H/HeNCRJ mice. 2004(2)
[12] CHAN R C, XIE H, ZHAO G P. Dendritomas formed by fusion of mature dendritic cells with allogenic human hepatocellular carcinoma cells activate autologous cytotoxic T lymphocytes. 2002(3). doi:10.1016/S0165-2478(2)00078-0
[13] HIRAMOTO J S, TSUNG K, BEDOLLI M. Antitumor immunity induced by dendritic cell-based vaccination is dependent on interferon-gamma and interleukin-12. 2004(1)
[14] IWASHITA Y, TAHARA K, GOTO S. Aphase I study of autologous dendritic cell-based immunotherpy for patients with unresectable primary liver cancer, 2003(3)
[15] TATSUMI T, TAKENHARA T, KANTO T. Administration of interleukin-12 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines in mouse hepatocellular carcinoma. 2001(20)
[16] LU S Y, SUI Y F, LI Z S. Superantigen-SEA gene modified tumor vaccine for hepatocellular carcinoma:an in vitro study. World J Gastroenterology2004(1)
[17] PENG B G, LIU S Q, KUANG M. Autologous fixed tumor vaccine:a formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma. 2002(4)
[18] LU J, LENG X, PENG J. Induction of cytotoxic T lymphocytes from the peripheral blood of a hepatocellular carcinoma patient using melanoma antigen-1(MAGE-1) peptide. Chin Med J2002(7)
[19] MENG W S, BUTTERFIELD L H, RIBAS A. Alpha-Fetoprotein-specific tumor immunity induced by plasmid prime-adenovirus boost genetic vaccination. 2001(24)
[20] FORGUES M, DIFILIPPANTONIO M J, LINKE S P. Involvement of Crml in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. 2003(15). doi:10.1128/MCB.23.15.5282-5292.2003
[21] CHUN E, LEE J, CHEONG H. Tumor eradication by hepatitis B virus x antigen-specific CD8+T cells in xenografted nude mice. 2003(3)
[22] WANG F S, LIU M X, ZHANG B. Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo. World J Gastroenterology2002(3)
[23] SAWAYAMA T, SAKAGUCHI K, SENOH T. Effects of pulsing procedure of IL-12 in combination with IL-2 on the activation of peripheral blood lymphocytes derived from patients with hepatocellular carcinoma, 2003(6)  

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