氧化亚氮分娩镇痛对母儿血ET和NO水平的影响-东南大学学报医学版

氧化亚氮分娩镇痛对母儿血ET和NO水平的影响

单位：东南大学附属中大医院,妇产科,江苏,南京,210009

分类号：R714.3

出版年·卷·期（页码）：2005·24·第五期（327-330）

摘要：

目的:研究氧化亚氮吸入性分娩镇痛母脐血一氧化氮(NO)及内皮素(ET)水平,了解其对孕妇及胎儿胎盘循环的影响.方法:将60例初产妇随机分为观察组和对照组,对照组除不给氧化亚氮外,其他产科处理与观察组相同,观察比较临床指标及母血、脐动脉、脐静脉ET和NO的水平.结果:观察组阵痛评分与对照组比差异有显著意义(P<0.01),两组临床指标(产程时间、分娩方式、胎儿窘迫、新生儿评分、产后出血等)无显著性差异(P>0.05),脐血ET水平明显低于对照组(P<0.05),两组母血ET、NO及脐血NO水平差异无显著性(P>0.05).结论:氧化亚氮吸入性分娩镇痛可使大多数产妇明显减轻疼痛,其对孕妇及胎儿胎盘循环无影响,是一种简便、安全的分娩镇痛方法.

Objective To study the levels of endothelin(ET) and NO in plasma of mother and fetus after analgesic labor with inhaling nitrous oxide gas and its effects on circulation of fetus and placenta.Methods 60 primiparae were randomly divided into the observational group and control group.The control group was given the same treatments as that in the observational group except for laughing gas.The degrees of clinical condition and levels of ET and NO in plasma of mother,umbilicalcord antery and vein between the two groups were measured.Result The score of labor pains in the observational group significantly was lower than that in the control one((P<)(0.01)).There was no significant difference in clinical condition(delivery process,delivery ways,Apgar scores,quantity of intrapartum hemorrhage).Levels of ET and NO in fetus was significantly lower than that in the control one((P<)(0.05)).There was no significant difference of ET and NO levels in mother and NO levels in fetus in two groups(P>(0.05)).Conclusion Analgesic labor with inhaling laughing gas can relief labor pains of most primiparae and shows no side effects on the circulation of fetus and placenta,which is safe,simple and easy to be accepted.

参考文献：

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