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拓扑异构酶Ⅱ与肿瘤化疗
作者:邓立春1 姜藻2 
单位:1.东南大学医学院附属江阴医院,肿瘤科,江苏,江阴,214431; 2.东南大学医学院附属中大医院,肿瘤科,江苏,南京,210009
关键词:拓扑异构酶Ⅱ 抗癌药物 药物耐受性 肿瘤 综述[文献类型] 
分类号:R730.54
出版年·卷·期(页码):2005·24·第四期(284-287)
摘要:

DNA拓扑异构酶Ⅱ(topoisomeraseⅡ,TopoⅡ)是一种调整DNA拓扑结构的核酶,在几乎所有DNA代谢过程中发挥重要作用,已成为抗癌药物的重要作用靶点.作者介绍了TopoⅡ抑制剂的作用机制及其与肿瘤耐药关系方面的研究进展.

Objective DNA topoisomerase Ⅱ is one kind of nuclear enzymes tnat can modify DNA topology. Playing an important role in most processes of the DNA mechanisms,it becomes an important target for a number of the most active and widely prescribed anticancer drugs. This article is mainly to illustrate the anticancer mechanism of TopoⅡ inhibitor and the relationship between TopoⅡ and mechanism of tumor drug resistance.

参考文献:

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