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羧甲基赖氨酸的研究进展
作者:魏芹 刘乃丰 
单位:东南大学附属中大医院,心内科,江苏,南京,210009
关键词:糖基化终末产物 高级 赖氨酸 表位 综述[文献类型] 
分类号:Q591.2, R543.02
出版年·卷·期(页码):2005·24·第四期(269-273)
摘要:

晚期糖基化终末产物(AGEs)是蛋白质、脂质或核酸等大分子物质的非酶糖基化产物.其在体内有多种不同的存在形式,研究最多的是羧甲基赖氨酸(CML),它是AGEs的主要抗原表位,体内分布广泛,在糖尿病并发症等病变和衰老的发生、发展中有重要作用.

Advanced glycation end products(AGEs) are formed in proteins, lipids or RNAse by combined nonenzymatic glycation and oxidation(glycoxidation) reaction. AGEs are a heterogenous class of compounds,out of which the most important is N ε-(carboxymethyl)lysine,a major immunological epitope in advanced glycation end products,and plays an important role in the pathogenesis of numerous diseases, including diabetes complications,atherosclerosis and in the normal aging process.

参考文献:

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