Objective To observe curative effect and safety of Kuhuang granule in treatment of jaundice virus hepatitis. Method The patients were randomly assigned into treatment group and control group. The treatment lasted for 3 weeks. Patients in treatment group were given oral taken with Kuhuang granule 6 g thrice per day, patients in control group were intravenously injected with 30 ml Kuhuang dissolved in 500 ml 5% glucose. Results There was a significant difference of serum total bilirubin between pre-treatment and post-treatment in both two groups, but there was no significant difference of serum total bilirubin between treatment group and control group. Serum total bilirubin returned to normal being 74.72% in treatment group and 79.79% in control group. There was no significant difference of clinical recovery, apparent effectiverate and effectiverate between the two groups, which were 32.97%, 41.75% and 19.78% respectively in the treatment group and 40.43%, 39.36%,10.64% in the control group. Conclusion The effect of jaundice regression and transaminase depression of Kuhuang granule and Kuhuang injection are similar in treatment of jaundice virus hepatitis.