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低温下血小板生理学性质的研究进展
作者:崔云1 刘璐1 黄成垠2 
单位:1.东南大学医学院,核技术研究中心,江苏,南京,210009; 2.江苏省血液中心,江苏,南京,210042
关键词:低温 保存 血小板 生理学 综述 
分类号:R331.143
出版年·卷·期(页码):2005·24·第三期(200-202)
摘要:

低温保存的血小板生理学性质可发生一系列改变,从而使血小板容易被损伤、激活,输入体内后很快被清除出血液,失去临床应用价值.为了有效地保护血小板,适应临床需求,必须充分了解这一点.作者就近年来有关低温下血小板生理学性质方面的研究进展作一综述.

Platelets stored at low temperature changes their physiology,resulting in cold-induced injury,activation and rapid clearance from the blood after being transfused into body, which makes platelets of little clinical value. In order to protect platelets effectively to adapt to clinical demand,we must fully  understand the changes.This essay  reviews recent studies on various physiological events of chilling platelets.

参考文献:

[1] Tablin F, WOLKERS W F, WALKER N J. Membrane reorganization during chilling:implications for long-term stabilization of platelets. 2001(2). doi:10.1006/cryo.2001.2355
[2] OLIVER A E, TABLIN F, NAOMI J. The internal calcium concentration of human platelets increases during chilling. 1999
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[10] RIVERA J, LOZANO M L, CORRAL J. Quality assessment of platelet concentrates supplemented with second-messenger effectors. 1999(2). doi:10.1046/j.1537-2995.1999.39299154726.x
[11] UPADHYA G A, STRASBERG S M. Platelet adherence to isolated rat hepatic sinusoidal endothelial cell after cold preservation. 2002(11). doi:10.1097/00007890-200206150-00012 

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