Objective To explore the effect of donor lymphocyte infusion on H22 hepatoma mice. Methods Forty H22 hepatoma mice were evenly divided into control group(group A),5FU group(group B),DLI group (group C), and 5FU+DLI group (group D). Survival time, tumor inhibitory rates, histopathologic changes, NK cell activities and interleukin-2 production were investigated. Results The survival time of group B and C was longer than group A (P<0.01) and there was a significant difference between group D and C (P<0.01). The tumor inhibitory rates of group B,C,D were 61.3%,34.7%,89.5%. Compared with group A and B, NK cells activities and interleukin-2 production were higher in group C and D (P<0.05). A lot of inflammatory cells could be seen under optic microscopy in group C and D. Conclusion Allogeneic lymphocytes infusion has antineoplastic effects on H22 hepatic cancer in mice. It is a potential and feasible adoptive cellular immunotherapy for solid tumor. |