>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
早发冠心病病因的遗传学研究进展
作者:张晓黎 陈忠 马根山 
单位:东南大学附属中大医院,心内科,江苏,南京,210009
关键词:冠心病 早发 病因 遗传学 基因 
分类号:R541.4, R394
出版年·卷·期(页码):2005·24·第二期(130-135)
摘要:

目前从基因水平阐明冠心病尤其是早发冠心病的发病机制是医学研究的热点和难点.作者对近年来脂质代谢、半胱氨酸代谢、肾素-血管紧张素-醛固酮系统、血小板膜糖蛋白及纤维蛋白原基因、纤溶酶原激活物抑制剂、基质金属蛋白酶、内皮型一氧化氮合酶、E-选择素、血小板反应素等一些相关基因多态性与早发冠心病有关的研究作一综述.

Now numerous researches have discovered that many genes are associated with the pathogenesis of coronary heart disease, especially in premature coronary heart disease. Here genetic polymorphisms of apopipoproteins,homocysteine,renin-angiotensin-aldosterone system,platelet glucoprotein and thrombin and matrix metaloproteinases,etc.were reviewed referring to the latest development in this field.

参考文献:

[1] 中华心血管病杂志编委会血脂异常防治对策组. 血脂异常防治建议, 1997
[2] HAUSER E R, MOOSER V, CROSSMAN A D. Design of the genetics of early onset cardiovascular disease (GENECARD)study. 2003(4)
[3] 彭澍, 彭健, 龚五星. 载脂蛋白E基因多态性与早发CHD的关系及其对血脂的影响. 中华医学遗传学杂志2001(5)
[4] 陈忠, 黄峻, 朱铁兵. 早发CHD患者同胞及子女血脂与载脂蛋白E基因多态性研究. 临床心血管病杂志2002(4). doi:10.3969/j.issn.1001-1439.2002.04.003
[5] NASSAR B A, DUNN J, TITLE L M. Relation of genetic polymorphism of apolipoprotein E,angiotensin converting enzyme,apolipoprotein B100 and glycoprotein Ⅲ and early onset of coronary heart disease, 1999
[6] KUMAR P, LUTHRA K, DWIVEDI M. Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction:a case-controlled study in Asian Indians in North India. 2003
[7] VIITANEN L, PIHLAJAMAKI J, MIETTINEN R. Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease. 2001(12)
[8] SYLVIE B, CYNTHIA R C, TRACEY A M N. Effect of acylglyceride content on the structure and function of reconstituted high density lipoprotein particles. 2001
[9] LILJA H E, SORO A, YLITALO K. A candidate gene studyin low HDL-cholesterol families provides evidence for the involvement of the APOA2 gene and the APOA1C3A4 gene cluster. 2002(1). doi:10.1016/S0021-9150(2)00040-0
[10] IKEWAKI K, MATSUNAGA A, HAN H. A novel two nucleotide deletion in the apolipoprotein A- Ⅰ gene,apoA- Ⅰ Shinbashi,associated with high density lipoprotein deficiency,corneal opacities,planar xanthomas,and premature coronary artery disease. 2004(1). doi:10.1016/j.atherosclerosis.2003.09.024
[11] 黄俊军. 家族性载脂蛋白B100缺陷症, 1996
[12] KALINA, CSASZAR A, CZEIZEL A E. Frequency of the R3500Q mutation of the apolipoproteinB-100 gene in a sample screened clinically for familial hypercholesterolemia in Hungary. 2001. doi:10.1016/S0021-9150(0)00648-1
[13] 张少敏, 胡应龙, 方卫华. 载脂蛋白B等位基因变异与早发CHD的关系. 中华心血管病杂志2003(2). doi:10.3969/j.issn.1007-5410.2003.02.001
[14] HONG S H, RHYNE J, ZELLER K. ABCA1 (Alabama):a novel variant associated with HDL deficiency and premature coronary artery disease. 2002(2). doi:10.1016/S0021-9150(2)00106-5
[15] CENARRO A, ARTIEDA M, CASTILLO S. A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia. 2003(3)
[16] TRIP M D, SMULDERS Y M, WEGMAN J J. Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease. 2002(7). doi:10.1161/01.CIR.0000028420.27813.C0
[17] POCATHIKORN A, GRANATH B, THIRY E. Influence of exonic polymorphisms in the gene for LDL receptor-related protein(LRP) on risk of coronary artery disease. 2003(1). doi:10.1016/S0021-9150(3)00087-X
[18] van BOCKXMEER F M, LIU Q, MAMOTTE C. Lipoprotein lipase D9N,N291S and S447X polymorphisms:their influence on premature coronary heart disease and plasma lipids. 2001(1). doi:10.1016/S0021-9150(0)00717-6
[19] 陈忠, 黄峻, 朱铁兵. 早发CHD患者脂蛋白脂酶基因多态性与血脂关系研究. 临床心血管病杂志2002(10). doi:10.3969/j.issn.1001-1439.2002.10.003
[20] SZCZEKLIK A, SANAK M, JANKOWSKI M. Mutation A1298C of methylenetetrahydrofolate reductase:risk for early coronary disease not associated with hyperhomocysteinemia, 2001(1)
[21] MAGER A, BATTLER A, BIRNBAUM Y. Plasma homocysteine,methy enetl etrahydrofolate reductase genotypes,and age at onset of symptoms of myocardial ischemia, 2002(8)
[22] RANJITH N, PEGORARO R J, ROM L. Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction, 2003(3)
[23] PINTO X, VILASECA M A, GARGIA-GIRALT N. Homocysteine and the MTHFR 677C- > T allele in premature coronary artery disease. Case control and family studies, 2001(1)
[24] 王小玲, 顾东风, 孙峰. 亚甲基四氢叶酸还原酶基因C667T突变与冠心病的连锁分析. 中华医学遗传学杂志2001(3)
[25] TSAI M Y, CARG U, KEY N S. Molecular and biochemical approaches in the identification of heterozygous for homocysteinuria. 1996. doi:10.1016/0021-9150(95)05748-X
[26] TSAI M Y, WELGE B G, HANSON N Q. Genetic causes of mild hyperomocysteinemia in patients with premature occlusivecoronary artery disease. 1999(1). doi:10.1016/S0021-9150(98)00271-8
[27] BERKOVICH O A, BAZHENOVA E A, VOLKOVA E A. I/D polymorphism in the angiotensin converting enzyme gene in men with myocardial infarction at young age, 2001(5)
[28] PETROVIC D, ZORC M, KANIC V. Interaction between gene polymorphisms of renin-angiotensin system and metabolic risk factors in premature myocardial infarction. 2001(4). doi:10.1177/000331970105200403
[29] SOBSTYL J, DZIDA G, PUZNIAK A. Angiotensin-converting enzyme gene insertion/deletion polymorphism in Polish patients with myocardial infarction, 2002(2)
[30] WEISS E J, BRAY P F, TAYBACK M. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis, 1996
[31] GOLDSCHMIDT-CLERMONT P J, COLEMAN L D, PHAM Y M. Higher prevalence of GPⅢⅠ A2 polymorphism in siblings of patients with premature coronary heart disease, 1999
[32] 马会利, 陈纪林, 冯军. 年轻心肌梗死患者纤维蛋白原基因βG455 A多态性研究. 中华心血管病杂志2002(2)
[33] MIKKELSSON J, PEROLA M, WARTIOVAARA U. Plasminogen activator inhibitor- 1( PAI- 1 ) 4G/5G polymorphism,coronary thrombosis,and myocardial infarction in middle-aged Finnish men who died suddenly, 2000
[34] VIITANEN L, PIHLAJAMAKI J, HALONEN P. Association of angiotensin converting enzyme and plasminogen activator inhibitor- 1 promoter gene polymorphisms with features of the imulin resistance syndrome in patients with premature coronary heart disease. 2001(1). doi:10.1016/S0021-9150(0)00705-X
[35] DORSCH M F, BARRETT J A, LAWRANCE R A. Premature coronary artery disease shows no evidence of linkage to loci encoding for tissue inhibitors of matrix metalloproteinases. 2003(10)
[36] GRANATH B, TAYLOR R R, van BOCKXMEER F M. Lack of evidence for association between endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in the Australian Caucasian population. 2001(4)
[37] NASSAR B A, BEVIN L D, JOHNSTONE D E. Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease. 2001(4)
[38] WENZEL R, ERNST M, ROHDE K. DNA polymorphisms in adhesion molecude genes:a new risk factor for esrly atherosclerosis, 1996
[39] ZHENG F, CHEVALIER J A, ZHANG L Q. An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease. 2001(1). doi:10.1034/j.1399-0004.2001.590110.x
[40] TOPOL E J, McCARTHY J, GABRIEL S. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. 2001(22). doi:10.1161/hc4701.100910
[41] BOEKHOLDT S M, TRIP M D, PETERS R J. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction, 2002(12)
[42] INBAL A, FREIM D, MODAN B. Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young mals, 1999
[43] BATALLA A, ALVAREZ R, REGUERO J R. Synergistic effect between apolipoprotien E and angiotensinogen gene polymorphisms in the risk for early myocardial infarction, 2000  

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 414715 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364