鼻NK/T细胞淋巴瘤的临床病理特征-东南大学学报医学版

鼻NK/T细胞淋巴瘤的临床病理特征

单位：1.东南大学附属中大医院,病理科,江苏,南京,210009； 2.江苏省肿瘤研究所,病理科,江苏,南京,210008

分类号：R739.62, R446.6

出版年·卷·期（页码）：2005·24·第二期（101-104）

摘要：

目的:探讨鼻NK/T细胞淋巴瘤的临床病理特点、诊断要点和相关预后因素.方法:分析总结13例鼻NK/T细胞淋巴瘤临床分期、病理特点及免疫组织化学(免疫组化)标记情况,并随访10年.结果:鼻NK/T细胞淋巴瘤病理特征为溃疡坏死组织背景中及其深部存在密集的异型淋巴细胞,肿瘤细胞具血管侵袭性,免疫组化显示表达CD3ε、CD45RO、C舾6、Pf和GrB.5年无瘤生存率和总生存率分别为46.1%和53.8%.结论:诊断鼻NK/T细胞淋巴瘤时要密切结合临床,免疫组化标记有助于鉴别诊断.肿瘤临床分期及生长状态与预后有关.

Objective To investigate the clinicopathological characteristics, diagnostic features and prognostic factors of nasal NK/T cell lymphoma. Methods 13 cases of nasal NK/T cell lymphoma were studied clinicopathologically and were detected by immunohistochemistry. All of cases had been followed up for 10 years.Results Nasal NK/T cell lymphoma was charaterized by ulcerated tissue densely populated by abnormal lymphoid cells, with large areas of necrosis,affecting both tumorous and uninvolved tissues. Tumor cells presented angioinvasive growth. The positive expression was observed for CD3ε,CD45RO, CD56, Pf and GrB. The 5-year disease-free survival (DFS) and overall survival (OS) rates were 46.1%and 53.8%, respectively.Conclusions The clinical manifestations should be combined with pathology in diagnosing the disease,and the immunohistochemistry is helpful for differential diagnosis. Ann Arbor stage and performance status were singnificant factors influencing DFS and OS.

参考文献：

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