CD1a和E-cadherin分子在尖锐湿疣皮损中的表达-东南大学学报医学版

CD1a和E-cadherin分子在尖锐湿疣皮损中的表达

单位：1.东南大学附属中大医院皮肤科； 2.南京医科大学第一附属医院,皮肤科,江苏,南京,210029

分类号：R752.53, R-33

出版年·卷·期（页码）：2006·25·第五期（366-369）

摘要：

目的:研究CD1a和E-cadherin分子在尖锐湿疣(CA)皮损中的表达情况及相互关系,探讨CA皮损局部免疫微环境的变化.方法:采用免疫组化法检测38例CA患者皮损和12名正常人包皮中CD1a和E-cadherin分子的表达.结果:CA皮损中CD1a和E-cadherin分子表达水平较正常包皮显著降低,CD1a和E-cadherin分子的表达呈正相关.结论:CA患者皮损CD1a和E-cadherin分子表达降低可能导致人乳头瘤病毒(HPV)抗原递呈障碍,在HPV逃逸机体免疫监视的过程中可能发挥重要作用.

Objective To study the expression of CD1a and E-cadherin molecules and their relationship in the lesions of condyloma acuminatum(CA),to observe the changes of immune microenvironment in the local CA lesions.Methods() The expression of CD1a and E-cadherin was detected by immunohistochemistry method in 38 lesions of CA and 12 specimens of normal prepuce.Results Compared with the normal control,the expression of CD1a and E-cadherin was decreased in CA lesions,respectively.A positive correlationship between the expression of CD1a and the expression of E-cadherin was observed.Conclusion The decreasing expression of CD1a and E-cadherin may cause the deficiency of human papillomavirus(HPV) antigen presentation,and it may play an important role in the process of HPV escaping from immunosurveillance.

参考文献：

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