磁共振扩散加权成像评价肝癌介入术后疗效的临床及动物实验研究-东南大学学报医学版

磁共振扩散加权成像评价肝癌介入术后疗效的临床及动物实验研究

单位：1.东南大学,临床医学院,江苏,南京,210009； 2.东南大学附属中大医院,放射科,江苏,南京,210009

分类号：R735.7, R730.4, R730.26

出版年·卷·期（页码）：2006·25·第五期（357-361）

摘要：

目的:应用磁共振扩散加权成像技术评价肝脏肿瘤介入手术疗效.方法:临床影像学诊断肝癌并行介入化疗栓塞术患者6例,VX2肿瘤造模新西兰大白兔2只.所有受检者及实验兔均先行常规T1WI、T2WI扫描,然后受检者在屏气下、实验兔在麻醉下进行2个不同扩散敏感因子b值的DWI扫描.结果:扩散扫描取不同b值时,介入手术术后与术前病灶表观扩散系数(ADC)的比值在110%以上时预后较好,低于110%时预后较差;病灶ADC值与肝脏ADC值的比值术后为术前的110%以上时预后较好,低于110%时预后较差.结论:磁共振扩散加权成像技术对评价肝脏肿瘤介入手术疗效似有指导价值.

Objective To evaluate the curative effect of chemoembolization of liver tumors by using of diffusion-weighted imaging(DWI) magnetic resonance(MR).Method 6 clinic liver tumor patients and 2 rabbits with VX2 tumor in liver first underwent routine T_1-weighted and T_2-weighted imaging of the whole liver,and then underwent DWI by using of 2 different b factors under breath-hold or general anaesthesia.Results By using of different b factors,chemoembolization postoperative apparent diffusion coefficient(ADC)_{focus}/preoperative ADC_{focus}≥110%,the prognosis was better,while the value<110%,the prognosis was worse;postoperative ADC_{focus}ADC_{liver}/ preoperative ADC_{focus}ADC_{liver}≥110%,the prognosis was better,while the value<110%,the prognosis was worse.Conclusion It seems that DWI and ADC value can evaluate the curative effect after chemoembolization of liver tumors.

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