Objective To investigate the evaluation of functional magnetic resonance imaging(fMRI) on diagnosis,differentiation and deciding the border of brain tumors.Methods Thirty-five intracranial tumor patients were recruited in this study.All the patients had undergone MR routine scanning,DWI and ^1H-MRS.The single values were calculated on enhancement areas of tumors,perienhancement regions and normal white matter.The difference of the mean relative ADCs were made by analysis of variance.Multivoxel ^1H-MRS was performed orderly.Spectra of three vowels were taken from the above different areas.Fitted areas in the spectrum for NAA,Cho,Cr,lac and other metabolite peaks were measured.Then the metabolite ratios were calculated for each voxel.Results The mean rADCs from enhancement areas of brain tumors were obtained significantly different between meningiomas and astrocytomas or metastases(P<(0.05)).The rADC values of perienhancement for astrocytemas,metastases and meningiomas were statistically significant(P<0.05).In multivoxel ^1H-MRS from the enhancement of the lesion,the metabolite ratios changed significantly by comparing with that of normal control brain tissues(P<0.05).In voxel from perienhancement region,the mean metabolite ratios revealed strong correlations among metabolite concentrations,tumor types(P<0.05).Conclusion fMRI with routine MRI will be useful in differentiation of tumors and deciding the border of tumors. |
