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米诺环素治疗脊髓损伤的研究进展
作者:王刚 吴小涛 
单位:东南大学附属中大医院,骨科,江苏,南京,210009
关键词:米诺环素 脊髓损伤 细胞凋亡 文献综述 
分类号:R681.54
出版年·卷·期(页码):2006·25·第三期(215-218)
摘要:

米诺环素(minocycline),化学名为二甲胺四环素,是第2代半合成四环素类药物的衍生物,具有相对分子质量小(为495 000)、亲脂性高、可通过血-脑屏障、口服易吸收的特点[1-2].其作为抗生素已成功应用于临床痤疮、泌尿系感染等的治疗.后来发现,米诺环素具有良好的抑制炎症反应作用,完全不同于其抗感染的作用机理,临床上应用于类风湿性关节炎等严重的人类炎症性疾病的治疗.临床实践证明,长期口服米诺环素无明显不良反应且安全有效.最近几年,人们通过研究其对卒中、肌萎缩性侧索硬化症(ALS)、Huntington病、颅脑创伤和脊髓损伤(SCI)的治疗作用发现,米诺环素还是一种安全有效的神经保护剂.

参考文献:

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