α-干扰素雾化吸入预防老年呼吸道感染-东南大学学报医学版

α-干扰素雾化吸入预防老年呼吸道感染

单位：东南大学医学院,附属南京第二医院,江苏,南京,210003

分类号：R56, R452

出版年·卷·期（页码）：2006·25·第二期（120-121）

摘要：

目的:观察α-干扰素雾化吸入对老年康复病人呼吸道感染的预防作用.方法:给予33例老年康复病人雾化吸入α-干扰素10万U加生理盐水20 ml,每天20 min,每月15 d,共12个月.观察雾化吸入前1年、雾化吸入后1年呼吸道感染次数以及雾化吸入前后免疫球蛋白IgG、IgA、IgM,补体C3、C4等体液免疫指标的变化.结果: 33例老年康复病人雾化吸入α-干扰素后呼吸道感染的次数较雾化吸入前显著减少(P<0.01),IgG、IgA、IgM较吸入前显著增加(P<0.05),而补体C3、C4较雾化吸入前显著减少(P<0.05).结论:雾化吸入α-干扰素对老年康复病人呼吸道感染有预防作用.

Objective To evaluate the preventing effect of aerosol α?interferon inhalation on respiratory infection in old patients.Methods 33 old patients were inhalated with α?interferon at a dose of 100 thousand units,20?min·d^{-1},and 15 days a months.The overall treating time was 12 months.Immunogical indices,namely:IgG,IgA,IgM,C_3 and C_4 were detected.The frequency of respiratory tract infection was compared between pre-inhataltion and post-treatment in the same patients.Results After aerolsol inhalation,the frequency of respiratory infection decreased((P<)(0.01)),IgG,IgA and IgM increased,and C_3 and C_4 declined,respectively.Conclusion Aerolsol inhalation of α-interferon may prevent respiratory infection in old patients.

参考文献：

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