复方米非司酮终止7周内早孕的临床观察-东南大学学报医学版

复方米非司酮终止7周内早孕的临床观察

单位：1.南京中医药大学,江苏,南京,210029； 2.东南大学,附属中大医院,江苏,南京,210009

分类号：R169.42

出版年·卷·期（页码）：2007·26·第六期（464-467）

摘要：

目的:探讨复方米非司酮配伍米索前列醇终止7周内宫内妊娠的临床效果.方法:100例欲行药物流产的早孕妇女使用随机数字表法分为:对照组50例,使用米非司酮配伍米索前列醇行药物流产;观察组50例,使用复方米非司酮配伍米索前列醇行药物流产.观察分析两组孕囊排出时间、完全流产率、阴道流血时间、流产后转经时间、服药不良反应,并行刮宫标本病理学检查.结果:与对照组相比,观察组孕囊排出平均时间[(2.77±1.63)h比(4.26±1.76)h]及阴道流血时间[(9.78±4.74)d比(13.26±5.29)d]明显缩短(P＜0.05),且服用米索前列醇前头晕反应及刮宫标本病理检查子宫内膜变化等亦有显著差异(P＜0.05),而完全流产率(79.59%比81.25%)、流产后转经时间[(33.23±5.36)d比(35.25±8.39)d]及除头晕以外的副反应等两组无显著差异(P＜0.05).结论:复方米非司酮配伍米索前列醇终止7周内早孕安全、有效、方便.

Objective To investigate the clinical effects of compound mifepristone combined with misoprostol on early pregnancy less than 7 gestational weeks.Methods 100 women of early pregnancy were randomly divided into two groups: 72 cases with routine abortion drug in control group and 71 cases taking compound mifepristone combined with misoprostol in observed group.The time of gestational sac discharge,bleeding and menstrual recovery,and side effects of taking drug,as well as pathological examination of curettage specimen were compared between two groups.Results Compared with the control group,the time of gestational sac discharge [(2.77±1.63)h vs(4.26±1.76)h] and post-abortion bleeding [(9.78±4.74)d vs(13.26±5.29)d] after abortion were significantly shortened(P<0.05),and pre-abortion dizziness and pathological changes of curettage specimen were significantly different(P<0.05) in observed group.The complete abortion rate and the time of post-abortion menstrual recovery decreased in observed group.Side effects except for dizziness were not obviously significant(P>0.05).Conclusion It is safe,effective and convenient to terminate the early pregnancy less than 7 gestational weeks with compound mifepristone combined with misoprostol.

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