Objective To evaluates the effect of balanced ultrafiltration,modified ultrafiltration,and combination of balanced ultrafiltration with modified ultrafiltration on inflammatory mediators in children ’s open-heart surgery.Method Sixty children with congenital heart disease were randomly divided into three groups: balanced ultrafiltration group(BUF group);modified ultrafiltration group(MUF group);and balanced ultrafiltration combined with modified ultrafiltration group(B+M group).Results Of these groups with similar clinical data the ultrafiltrated volumes were(415±136)ml,(294±81)ml and(726±153)ml respectively.Tumor necrosis factor(TNF),interleukin-8(IL-8) were measured at the beginning of cardiopulmonary bypass(CPB),30 min later,at the cessation of CPB,at the cessation of MUF(MUF group and B+M group),and 8 hours postoperatively.During CPB,the concentrations of TNF and IL-8 increased significantly in MUF group and did not change significantly in BUF and B+M groups.In the period of MUF,TNF and IL-8 increased.Conclusion The study shows that ultrafiltration can filter out the inflammatory mediators,but only BUF can decrease their concentrations.Moreover,MUF only can condense blood.Combination of BUF and MUF maintains low levels of inflammatory mediators,and postoperatively condenses blood. |
