血清CA125和CA199在子宫内膜异位症中的临床诊断价值-东南大学学报医学版

血清CA125和CA199在子宫内膜异位症中的临床诊断价值

单位：1.南京医科大学,江苏,南京,210029;南京医科大学,附属南京市妇幼保健院,江苏,南京,210004； 2.南京医科大学附属南京第一医院,妇产科,江苏,南京,210006； 3.南京医科大学第一附属医院,临床生殖医学中心,江苏,南京,210029

关键词：子宫内膜异位症糖类抗原-125 糖类抗原-199

分类号：R711.71

出版年·卷·期（页码）：2007·26·第六期（446-449）

摘要：

目的:探讨血清CA125联合CA199水平测定在子宫内膜异位症(EM)中的临床诊断价值.方法:对经病理证实的93例EM(EM组)及45例非EM(对照组)患者,术前1 d采用磁性分离酶联免疫法测定血清CA125及CA199水平,并对48例EM患者术后1个月的血清CA125及CA199水平进行测定.结果:EM患者血清CA125水平为(40.02±41.87)U·ml-1,CA199水平为(25.08±23.76)U·ml-1,显著高于对照组(P＜0.01).EM组患者血清中CA125敏感性和特异性分别为34.92%和73.10%,CA199敏感性和特异性分别为19.05%和79.31%,以血清CA125和CA199均阳性为标准,敏感性下降为18.71%,特异性增加至100.00%.48例EM患者术后1个月的血清CA125及CA199水平与术前1 d测定水平比较,差异有显著性(P＜0.01).结论:血清CA125联合CA199水平测定对EM有较好的辅助诊断价值,并能提高诊断的准确性,且术后测定血清CA125、CA199水平有助于观察EM的疗效.

Objective To evaluate role of serum CA125 level combined with serum CA199 level in diagnosing endometriosis.Methods 93 women with pelvic endometriosis confirmed by pathology(EM group) and 45 women without endometriosis(control group) were detected of serum CA125 and CA199 level with magnetic antibody immunity assay one day before surgery.And 48 women with endometriosis were detected of serum CA125 and CA199 level one month after surgery.Results The average levels of serum CA125(40.02±41.87) and CA199(25.08±23.76) of EM group were all obviously higher than the control group(P<0.01).The specificity and sensitivity of serum CA125 of EM group was 34.92% and 73.10% respectively,and CA199 was 19.05% and 79.31%.If standardized by both positive of serum CA125 and CA199,the sensitivity descended to be 18.71%,specificity increased to be 100%.Difference in serum CA125 and CA199 level of 48 women with endometriosis between previons day before surgery and one month after surgery was significant(P<0.01).Conclusion Serum CA125 level combined with serum CA199 level has an important value in the diagnosis of endometriosis and improves the diagnostic accuracy for endometriosis.Postoperative detection is helpful for observeing efficacy

参考文献：

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