共刺激信号B7-1的缺失促进了胃癌生成及转移-东南大学学报医学版

共刺激信号B7-1的缺失促进了胃癌生成及转移

单位：1.江苏省镇江卫生学校,212004； 2.南京医科大学第一附属医院,普外科,江苏,南京,210029

分类号：R735.2

出版年·卷·期（页码）：2007·26·第六期（407-408）

摘要：

目的:探索共刺激信号B7-1的表达缺失对胃癌生成及淋巴结转移的影响.方法:应用RT-PCR技术检测44例胃癌组织、癌旁组织标本中B7-1 mRNA的表达,分析其与胃癌病理学特征的关系.结果:所有癌旁胃组织都有B7-1基因的表达,而44例胃癌组织中只有8例有表达,癌旁正常胃组织与胃癌组织中B7-1基因表达率差异有显著性(χ2=9.14,P＜0.05).有淋巴结转移的35例胃癌组织中,1例有B7-1基因表达,无淋巴结转移的9例胃癌组织中有7例检测到B7-1 mRNA的表达,有淋巴结转移的胃癌组织中B7-1 mRNA的表达率显著降低(χ2=23.66,P＜0.05).结论:B7-1 mRNA表达缺失促进了胃癌生成及淋巴结转移.

Objective To investigate the relationship between the loss of B7-1 expression and oncogenesis,and lymph node metastasis in gastric carcinoma.Method Using RT-PCR technique,specimens from 44 patients with gastric cancer were detected their expression of B7-1.Results All normal gastric tissues were detected to have the expression of the B7-1 gene,while 36 out of 44 gastric cancer tissues did not show any detectable B7-1 mRNA expression,there were significant differences between the two groups(χ 2=9.14,P<0.05).Furthermore,only one gastric cancer tissues in 35 patients with lymph node metastasis had B7-1 mRNA expression.B7-1 mRNA expression was negatively correlated with lymph node metastasis(χ 2=23.66,P<0.05).B7-1 positive isolates had less lymph node metastases than those of B7-1-negative ones(P<0.05).Conclusion Loss of B7-1 expression facilitates oncogenesis and lymph node metastasis in gastric carcinoma.

参考文献：

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