Ⅱb期宫颈癌的术前介入化疗-东南大学学报医学版

Ⅱb期宫颈癌的术前介入化疗

单位：东南大学医学院附属江阴医院,妇产科,江苏,江阴,214400

分类号：R737.33, R730.55, R730.53

出版年·卷·期（页码）：2007·26·第五期（366-368）

摘要：

目的:比较术前治疗方式对Ⅱb期宫颈癌疗效的影响.方法:48例手术治疗的Ⅱb期宫颈癌患者,根据术前辅助治疗方法,采用回顾性分析,随机分为术前介入组和术前后装组,比较两组的近期疗效、盆腔淋巴结转移和生存率.结果:术前介入组局部肿瘤消退明显,近期有效率为92%,较术前后装组的43%明显提高(χ2＝6.74,P＜0.05).术前介入组淋巴结转移率20%,明显低于术前后装组的52%(χ2＝5.42,P＜0.05).术前介入组3年生存率84%,明显高于术前后装组的52%(χ2＝5.64,P＜0.05).结论:介入化疗是治疗Ⅱb期宫颈癌有效的术前辅助治疗手段,能有效控制局部肿瘤,减少淋巴结转移,提高生存率.

Objective To compare the effect of preoperative treatment modality on cervical carcinoma in stage Ⅱb.Method 48 patients with stage Ⅱb cervical carcinoma were divided into two groups according to preoperative treatment.There are 25 patients with intraarterial chemotherapy(Group1) and 23 patients with radiotherapy(Group2) before operation.Short-term effect,lymphnode metastasis,and survival rate were analysed.Results The short-term effective rates of group 1 and group 2 were 92% and 43%,group 1 was significantly higher than that in group 2(χ2=6.74,P<0.05).The rate of lymphnode metastasis in group1 was 20%,and it was significantly lower than that in group 2(52%)(χ2=5.42,P<0.05).The three-year survival rate was 84% in group 1,and it was significantly higher than that in group 2(52%)(χ2=5.64,P<0.05).Conclusion Preoperative intraarterial chemotherapy is effective to cervical carcinoma in stageⅡb,it can shrink tumor size,decrease the lymphnode metastasis rate,and elevate survival rate.

参考文献：

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