体外循环围手术期凝血功能及血小板数量变化的临床观察-东南大学学报医学版

体外循环围手术期凝血功能及血小板数量变化的临床观察

单位：东南大学附属中大医院,检验科,江苏,南京,210009

分类号：R654.1, R446.11

出版年·卷·期（页码）：2007·26·第五期（360-362）

摘要：

目的:研究体外循环术期间凝血功能、抗凝血功能、纤溶系统活性和血小板数量的改变.方法:测定35例进行心脏手术患者体外循环术前、中、后的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、血小板(PLT)、抗凝血酶(AT)和D二聚体(D-Dimer)指标.结果:体外循环术中和术后凝血指标PT、APTT、TT与体外循环术前相比均明显延长,P＜0.01.FIB、PLT、D-Dimer体外循环术中和术后与体外循环术前相比均降低,P＜0.01或P＜0.05.结论:体外循环术可以导致凝血、抗凝血、纤溶系统活性和血小板数量的改变,引起术后非外科性出血.

Objective To observe changes of coagulant function and platelet quantity during perioperative extracorporeal circulation.Method The levels of PT,APTT,TT,FIB,AT,PLT and D-Dimer were detected in 35 perioperative patients,who underwent intracardiac surgery under extracorporeal circulation.Results The levels of PT,APTT and TT during and after operation were obviously longer than those before operation(P<0.01).However,the levels of FIB,PLT and D-Dimer during and after operation were obviously lower than those before operation(P<0.05 or P<0.01).Conclusion The extracorporeal circulation operation might effect the function of coagulant,anticoagulant,fibrinolytic system and platelet quantity,which induce non-surgical hemorrhage after operation.

参考文献：

[1] 王振义, 李家增, 阮长耿. 血栓与止血--基础理论与临床, 1996
[2] 朱光华. 体外循环与血液透析后凝血、止血障碍. 中国小儿急救医学2006(4). doi:10.3760/cma.j.issn.1673-4912.2006.04.004
[3] 李燕平. 体外循环围手术期凝血因子的变化. 国外医学(临床生物化学与检验学分册)2002(3). doi:10.3969/j.issn.1673-4130.2002.03.026
[4] 谭齐贤, 张树平. 临床血液学和血液检验, 1990

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