氯化锶治疗去卵巢大鼠骨质疏松的实验观察-东南大学学报医学版

氯化锶治疗去卵巢大鼠骨质疏松的实验观察

单位：1.东南大学,临床医学院,江苏,南京,210009； 2.东南大学医学院附属徐州医院,骨科,江苏,徐州,221009

分类号：R591.1, R-33

出版年·卷·期（页码）：2007·26·第五期（355-358）

摘要：

目的:研究氯化锶对切除卵巢雌性大鼠骨质疏松的影响及作用机制.方法:通过切除大鼠卵巢建立骨质疏松模型,随机分为治疗前组、对照组、低剂量组、高剂量组和假手术组,每组10只,治疗12周,观察治疗前后模型动物骨代谢及血清和尿中相关指标的变化.结果:低剂量组和高剂量组的骨密度(BMD)明显高于对照组,高剂量组的BMD接近假手术组;低剂量组和高剂量组的血清骨钙素明显高于对照组,尿羟脯氨酸/肌酐低剂量组和高剂量组低于对照组.低剂量组和高剂量组TRAP活性降低,接近正常组水平.结论:锶盐对骨质疏松模型鼠有增加骨量的作用,且具有促进骨形成和抑制骨吸收的双重功效.

Objective To investigate whether strontium chloride is effective for the restoration of bone loss in female rats with osteoporosis induced by ovariectomy.Methods The model of osteoporosis was established by ovariectomy in rats,and then the rats were given different doses of strontium chloride doses,the treatment of 12 weeks,before and after treatment of animal models of bone mineral density(BMD),serum and urine related indicators were measured.Results BMD in the strontium chloride treatment groups was significantly higher than that in the control group and high dose group of BMD was close to that in the sham group.Compared with the control group,serum BGP in the treatment groups was increased.HOP/Cr in the treatment groups was lower than that in the control group.TRAP activity was close to the normal level.Conclusion Strontium salt can increase bone mass of rats modeles of osteoporosis,which can promote bone formation and inhibite bone resorption.

参考文献：

[1] 郭世绂, 罗先正, 邱贵兴. 骨质疏松基础与临床, 2001
[2] STEGMAN M R, RECKER P R, DAVIES K M. Fracture risk asdetermined by prospective study designs. 1992. doi:10.1007/BF01623185
[3] MARIE P J. Effects of strontium on bone formation and bone cells, 1996
[4] PORS N S. The biological role of strontium. 2004(3). doi:10.1016/j.bone.2004.04.026
[5] BPARBARA A, DELANNOY P, DENIS B G. Normal matrix.mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells, 2004(4)
[6] AMMAN P, SHEN V, ROBIN B. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. 2004(12). doi:10.1359/JBMR.040906
[7] 王大申, 张梅. 骨钙素与骨代谢, 1985(4)
[8] DAVID M S, JOHN S A, ROBERT M N. Deficient production of 1α,25-dihydroxy vitamin D in elderly osteoporosis patients, 1981
[9] DELMAS P D. Biochemical marker of bone turnover for the clinical assessment of metabolic bone disease, 1990
[10] MARIE P J, HOTT M, MODROWSKI D. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats, 1993(5)

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录