胃癌患者外周血骨桥蛋白检测的临床意义-东南大学学报医学版

胃癌患者外周血骨桥蛋白检测的临床意义

单位：1.东南大学基础医学院,病理学与病理生理学系,江苏,南京,210009； 2.浙江大学医学院附属第二医院,检验科,浙江,杭州,310009

分类号：R735.2

出版年·卷·期（页码）：2007·26·第四期（243-245）

摘要：

目的:探讨外周血骨桥蛋白(osteopontin,OPN)作为胃癌肿瘤标志物检测的临床意义.方法:应用酶联免疫吸附试验(ELISA)和放射免疫分析技术(RIA)检测63例胃癌患者手术前后外周血OPN和癌胚抗原(carcinoembryonic antigen,CEA)的质量浓度,对照组为40例正常健康志愿者.结果:胃癌患者外周血OPN和CEA检测的敏感性分别为69.8%和57.1%,特异性分别为92.5%和87.5%,联合检测的敏感性为77.8%.OPN和CEA的质量浓度与胃癌的临床分期、淋巴结和器官转移有关,与胃癌的组织学分型及大小无关.治疗前后两种标志物的质量浓度具有显著差异.结论:OPN是一种较为理想的胃癌肿瘤标志物,与CEA联合检测能提高胃癌诊断的敏感性.

Objective To evaluate the clinical significance of osteopontin(OPN) as a tumor marker in peripheral blood of patients with gastric cancer.Methods Serum levels of OPN and carcinoembryonic antigen(CEA) in gastric cancer(n=63) in pre-and post-operation and in control group(n=40) were detected by ELISA and RIA methods.Results The sensitivity of OPN and CEA in patients with gastric cancer was 69.8% and 57.1%,and the specificity of OPN and CEA was 92.5% and 87.5%,respectively.The sensitivity of OPN combined with CEA was 77.8%.Serum levels of OPN and CEA were related with PTNM stage,lymph node involvement and presence of distant metastases and not related with histological type and size.Pre-and post-operative levels of the two markers were obviously different.Conclusion OPN,a potential tumor marker,improves the sensitivity of diagnosis of gastric cancer when combined with CEA.

参考文献：

[1] RITILING S R, CHAMBERS A F. Role of osteopontin in tumour pmgression. 2004(10). doi:10.1038/sj.bjc.6601839
[2] 陈道达. 胃肿瘤, 2001
[3] CRAIG A M, BOWDEN G T, CHAMBERS A F. Secreted phosphopmtein mRNA is induced during multi-stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts. 1990(1). doi:10.1002/ijc.2910460124
[4] VOGT M H, LOPATINSKAYA L, SMITS M. Elevated osteopontin levels in active relapsing-remitting multiple sclerosis. 2003(6). doi:10.1002/ana.10606
[5] SENGER D R, PERRUZZI C A, GRACEY C F. Secreted phosphoproteins associated with neoplastic transformation:close homology with plasma proteins cleaved during blood coagulation, 1988(20)
[6] SINGHAL H, BAUTISTA D S, TONKIN K S. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival. 1997(4)
[7] FEDARKO N S, JAIN A, KARADAG A. Elevated serum bone sialoprotein and osteopontin in colon,breast,prostate,and lung cancer. 2001(12)
[8] SCHORGE J O, DRAKE R D, LEE H. Osteopontin as an adiunet to CA125 in detecting recurrent ovarian cancer. 2004(10). doi:10.1158/1078-0432.CCR-03-0365
[9] BRAKORA K A, LEE H, YUSUF R. Utility of osteopontin as a biomarker in recurrent epithelial ovarian cancer. 2004(2). doi:10.1016/j.ygyno.2004.01.050

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录