目的:检测心肌肌钙蛋白I(cTn I)异常病人血清中结缔组织生长因子(CTGF)水平的变化,探讨CTGF在心肌损伤病人血清中表达的意义.方法:化学发光法检测血清中cTn I水平,并根据cTn I水平分组;利用生物素亲和素EIA分析法检测各组病人血清中CTGF水平.结果:80例病人血清标本按cTn I水平分为Ⅰ、Ⅱ、Ⅲ 3组,CTGF平均水平依次为(13.04±6.85)、(21.67±8.35)及(35.06±24.12)ng·ml-1.其中,Ⅱ、Ⅲ组血清CTGF水平明显高于正常对照组(均P＜0.05),Ⅰ组与正常对照组比较差异不显著(P＞0.05),Ⅱ、Ⅲ组与Ⅰ组比较差异显著(均P＜0.05),Ⅱ组与Ⅲ组比较差异显著(P＜0.05).结论:CTGF在心肌损伤以及心肌梗死后表达上调,可能与心肌纤维化关系密切.

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