Objective To examine the malondialdehyde(MDA) and advanced oxidation protein products(AOPP) in patients with acute coronary syndrome(ACS) and discuss the relationship between lipid peroxidate with the development of ACS.Methods The collected 73 patients with acute myocardial infarction(AMI)(including 46 selective PCI patients & 27 emergency PCI patients),49 patients with unstable angina pectoris(UA) and 21 patients with non-coronary artery disease(non-CAD) all underwent coronary angiography.Plasma were collected at immediately,post-24 hours and post-48 hours after patients were recruited.MDA was measured with TBA methods and AOPP was determined by measurements of optical density via spectrophotometry.Results Compared with normal group(non-CAD),significantly higher plasma MDA were seen in all patients with AMI(P<0.05),including selective PCI and emergency PCI patients,but it had no difference between the patients with UA and patients with non-CAD(P>0.05).Compared with normal group(non-CAD),significantly higher plasma AOPP were detected in the patients with AMI(including selective PCI and emergency PCI group)& UA(P<0.05).Comparing emergency PCI group,significantly higher plasma AOPP also existed in the selective PCI group(P<0.01).Conclusion Lipid peroxidation significantly increases in patients with AMI and it may have important effects in development of ACS. |