血清瘦素质量浓度与胃癌患者营养状态之间的关系-东南大学学报医学版

血清瘦素质量浓度与胃癌患者营养状态之间的关系

单位：1.南京医科大学附属南京第一医院,消化科,江苏,南京,210006； 2.南京市医学放射免疫检测中心,江苏,南京,210006

分类号：R735.2

出版年·卷·期（页码）：2007·26·第一期（49-51）

摘要：

目的:研究血清瘦素质量浓度与胃癌患者营养状态之间的关系.方法:分别测定37例胃癌患者和11例正常对照者血清瘦素以及身高体质量指数(BMI)、血白蛋白(ALB)、肱三头肌皮褶厚度(TSF)、上臂中心肌肉周径(MAC)、理想体质量百分比(NW%)和总淋巴细胞计数(LYM).胃癌患者分为营养不良(Ⅰ组)和非营养不良(Ⅱ组)两组.结果:血清瘦素质量浓度与BMI、NW%、TSF、MAC呈正相关(P＜0.001),而与ALB、LYM无相关性;胃癌组血清瘦素质量浓度Ⅰ组显著低于Ⅱ组及对照组,其中胃癌患者男性与女性血清瘦素质量浓度无差异.结论:胃癌营养不良患者的瘦素质量浓度低于非营养不良者及正常者,临床上可作为营养不良的诊断指标之一.

Objective To find the relationship between serum leptin concentration and malnutrition in gastric cancer patients.Methods The serum leptin concentration,body mass index(BMI),normal weight%,triceps skin-fold thickness(TSF),mid-arm circumference(MAC),albumin(ALB) and lymphocyte count(LYM) of 37 gastric cancer patients and 11 normal control were determined.The gastric cancer patients were divided into malnutrition group(14 cases)and non-malnutrition group(23 cases);Results The serum leptin concentration of all patients(48 cases) were positively correlated with BMI,NW%,TSF and MAC(P<0.001),not with ALB and LYM;Serum leptin concentration in malnutrition group were significantly lower than non-malnutrition group and control group,there were no difference between male and female.Conclusion The serum leptin levels in gastric cancer malnutrition are lower than non-malnutrition and normal group,which can be one of the diagnostic criteria for malnutrition.

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