非小细胞肺癌LRP、c-erbB-2蛋白表达与辅助化疗疗效相关性的研究-东南大学学报医学版

非小细胞肺癌LRP、c-erbB-2蛋白表达与辅助化疗疗效相关性的研究

单位：东南大学医学院附属南京第二医院,肿瘤内科,江苏,南京,210003

分类号：R734.2, Q786

出版年·卷·期（页码）：2008·27·第六期（451-453）

摘要：

目的:研究非小细胞肺癌肺耐药相关蛋白(LRP)、c-erbB-2蛋白表达与辅助化疗疗效之间的相关性.方法:收集61例非小细胞肺癌的病理标本,通过免疫组化检测LRP、c-erbB-2的表达,61例患者均接受4～6个周期化疗,其中19例采用MVP(MMC加VDS加DDP)方案,17例采用NP(NVB加DDP)方案,25例采用TP(TXL加DDP)方案,对疗效与免疫组化结果进行统计学处理.结果:化疗前LRP表达阳性者的化疗有效率为35.29%,与阴性者(为77.78%)相比具有显著的统计学差异(P＜0.05).化疗前c-erbB-2蛋白表达阳性者的化疗有效率为38.93%,与阴性者(为62.50%)相比也具有显著的统计学差异(P＜0.05).结论:在肺癌的辅助化疗中,LRP、c-erbB-2蛋白的表达与疗效有着重要的关联,在化疗之前对LRP及c-erbB-2蛋白的检测有助于预测化疗疗效及预后.

Objective To study the relation between the expression of LRP and c-erbB-2 and adjuvant chemotherapy in non small cell lung cancer(NSCLC).Methods 61 samples of NSCLC were collected to detect the expression of LRP and c-erbB-2 using immunohistochemistry.And 61 patients all received 4 or 6 cycles of chemotherapy,among whom 19 received MMC+VDS+DDP,17 NVB+DDP,25 TXL+DDP.Results The effectiveness of those with positive LRP before chemo-therapy was 35.29%,lower than 77.78% of those with negative LRP which was.The effectiveness for c-erbB-2 positive patients before chemotherapy was 38.93%,lower than 62.50% for the c-erbB-2 negative patients.Conclusion The expressions of LRP and c-erbB-2 are closely correlated with the effect in adjuvant chemotherapy.The detection of the expression of LRP and c-erbB-2 before chemotherapy can help to predict curative effect and prognosis.

参考文献：

[1] 王洁, 刘叙仪, 蒋薇. LRP、MRP、MDR1基因在非小细胞肺癌中的表达及其临床意义. 中华肿瘤杂志2000(4)
[2] MESCHINI S, MARRA M, CALCABRINI A. Role of the lung resistance-related protein (LRP) in the drug sensitivity of cultured tumor cells. 2002(4). doi:10.1016/S0887-2333(2)00035-8
[3] HORVATH V, BLANAROVA O, SVIHALKOVA-SINDLEROVA L. Platinum (Ⅳ) complex with adamantylamine overcomes intrinsic resistance tocisp latin in ovarian cancer cells. 2006(1). doi:10.1016/j.ygyno.2005.11.016
[4] WANG W, KE S, CHEN G. Effect of lung resistancerelated protein on the resistance to cisp latin in human ovarian cancer cell lines, 2004(6)
[5] PRENZEL N, FISCHER O M, STREIT S. The epidermal growth factor receptor family as a cent ral element for cellular signal transduction and diversification. 2001(1). doi:10.1677/erc.0.0080011
[6] TORRE E A, SALIMBENI V, FULCO R A. The erbB-2 oneogene and chemotherapy:a mini review, 1997

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录