Objective To study the relationship between blood lipid levels in pregnant women and the rate of macrosomia.Methods All of 2 244 pregnant women with normal glucose tolerance were allocated into this study,including macrosomia group(n=144) and normal group(n=2 100).The blood samples were collected and evaluated for FBG,TC,TG,HDL-C,LDL-C,Apo AⅠ and Apo B.Results (1)The TG and Apo B levels were significantly increased in macrosomia group compared with those in normal group(P<0.001).However,the HDL-C and Apo AⅠ levels in macrosomia group were significantly lower than those in normal group(P<0.05).(2)The percentage of macrosomia with hyperlipidemia gravida was much higher than that with normal gravida(P=0.011).(3) The weight of newborn child was positively correlated with blood lipid levels(TG) in pregnant women (r=0.315,P<0.001).Conclusions The blood lipid levels in pregnant women with normal glucose tolerance is one of the effective indices to predict perinatal outcomes.Reducing blood lipid levels can decrease the occurrence of macrosomia.