Objective To investigate the cause and combined therapy of pregnancy accompanied with severe hepatopathy,and to study the influence of pregnancy outcome of the choice of time and method for termination of pregnancy.Method Clinical data of 14 cases,including etiological factor,clinical symptom,treatment and pregnancy outcome,were analyzed.Results Hepatitis B virus infection was identified in 9 out of 14 cases (64.3%).Upon the final diagnosis,they were given combined therapy which include the protection of liver and use of blood plasma,albumin,fibrinogen and prothrombin complex as soon as possible.When the vital sign of patients were quite stable,13 cases were terminated pregnancy by cesarean section.12 mothers and 13 babies were survival,except a woman died.And one patient who delivered by vagina was survived,but her newborn baby died of prematurity.Conclusion Infection of hepatitis B virus mainly causes pregnancy accompanied by severe hepatitis.Once the patients are diagnosed,pregnancy must be terminated by cesarean section or vaginal delivery,which prevents patient situation from deteriorating.