目的:研究新型抗肿瘤药Saposin C-dops对小鼠免疫功能的影响.方法:采用实效药量及其10倍药量的Saposin C-dops给雌性B6小鼠进行连续7 d腹腔注射给药后,检测小鼠脾脏中与肿瘤免疫相关的免疫细胞、血清中的细胞因子和IgG含量的变化,从而判断其在正常药量和超量情况下对健康小鼠免疫力的影响.结果:Saposin C-dops在正常用药量情况下对小鼠免疫功能有显著激活效应,这种激活效应不是剂量依赖的,而且在超量应用的情况下对小鼠免疫功能不产生负面影响.结论:Sapo-sin C-dops具有免疫激活剂的作用,能增强小鼠的免疫功能.

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