ICU铜绿假单胞菌、鲍曼不动杆菌的耐药性分析-东南大学学报医学版

ICU铜绿假单胞菌、鲍曼不动杆菌的耐药性分析

单位：浙江大学医学院附属第一医院检验科,浙江杭州,310003

分类号：R378.99

出版年·卷·期（页码）：2008·27·第五期（370-372）

摘要：

目的:了解本院ICU铜绿假单胞菌与鲍曼不动杆菌对常用抗生素的耐药情况,以指导临床抗生素的合理使用.方法:回顾性分析本院2006年1月至2007年1月ICU分离的铜绿假单胞菌和鲍曼不动杆菌的药敏结果,剔除重复菌株,药敏试验采用K-B纸片扩散法. 结果:102株铜绿假单胞菌对常用抗菌药物有不同程度的耐药,其中对美罗培南、亚胺培南、头孢他啶、头孢哌酮/舒巴坦、派拉西林/他唑巴坦、环丙沙星和丁胺卡那的敏感性分别为76.3%、75.1%、75.9%、72.7%、83.2%、72.3%和71.1%.252株鲍曼不动杆菌除对头孢哌酮/舒巴坦和氨苄西林/舒巴坦的敏感率为63.5%和43.7%,其余均≤20%. 结论:ICU的铜绿假单胞菌、鲍曼不动杆菌对常用抗菌药物的耐药现象十分严重,必须加强耐药监测,根据药敏结果合理用药.

Objective To investigate the antibiotic resistance of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from ICU in our hospital,and to guide the rational uses of antibiotic.Methods The antibiotic resistance of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from ICU during January 2006 to January 2007 in our hospital was reviewed retrospectively,repeated strains were kicked out and antimicrobial susceptibility testing was carried out by means of Kirby-bauer(KB).Results 102 strains of Pseudomonas aeruginosa and 252 strains of Acinetobacter baumannii were analyzed.The susceptibility rates of Pseudomonas aeruginosa to meropenem,imipenem,ceftazidime,cefoperazone/sulbactum,piperacillin/tazobactam,ciprofloxacin and amikacin were 76.3%,75.1%,75.9%,72.7%,83.2%,72.3% and 71.1%,respectively.The most active agent against Acinetobacter baumannii were cefoperazone/sulbactum(63.5%) and ampicillin/ sulbactum(43.7%),the others were ≤20%.Conclusion The antimicrobial resistance of Pseudomonas aeruginosa and Acinetobacter baumannii is serious in ICU,the surveillance for drug resistance should be emphasized.

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