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肾小管上皮细胞间充质转分化分子机制的研究进展
作者:周凌 刘必成 
单位:东南大学附属中大医院,肾内科,江苏,南京,210009
关键词:肾间质纤维化 转分化 信号传导 
分类号:R692
出版年·卷·期(页码):2008·27·第四期(312-315)
摘要:

肾间质纤维化是多种肾脏疾病发展到一定阶段常见的病理改变,其严重程度不仅影响肾功能,而且与肾病的预后有着密切联系.肾间质的基质成分由成纤维细胞合成分泌,研究表明,肾间质成纤维细胞主要有3个来源:(1)肾脏固有的间质成纤维细胞;(2)循环而来的间充质细胞;(3)肾小管上皮细胞间充质转分化(epithelial mesenchymal transition,EMT).其中EMT在肾小管间质纤维化中的作用正越来越受到重视,作者对EMT分子机制的研究进展进行综述.

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