目的:检测不稳定型心绞痛(UA)患者在治疗前后血清中超敏C反应蛋白(hsCRP)水平的变化,评估其抗炎效果.方法:用增强免疫透射比浊法测定161例UA患者入院及出院时血清中的hsCRP水平,并根据危险度将UA患者分为Ⅰ、Ⅱ、Ⅲ级,以正常健康体检者60例血清标本为对照组.结果:UA患者入院时和出院时的hsCRP水平分别为(7.81±2.80) mg·L-1及(6.68±2.89) mg·L-1,均显著高于正常对照组[(1.36±0.78)mg·L-1,均P<0.01];随危险度分级的提高,患者的hsCRP水平相应增高,分别为(3.65±2.19)、(8.47±2.86)、(11.32±3.34) mg·L-1;经治疗出院时,除Ⅰ级差异不明显外,Ⅱ、Ⅲ级患者的hsCRP水平降低显著,分别为(7.23±2.76) mg·L-1 (P<0.05)和(9.16±3.10) mg·L-1(P<0.05).结论:UA患者hsCRP平均水平明显高于正常人,并随危险度分级提高而升高;hsCRP可以作为UA抗炎治疗效果好转的指标.

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