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缺氧对小鼠背根神经节细胞IK电流的影响
作者:李爱1 曹雪松2 曹雪红1 高琳琳1 胡新武1 张亮品1 陈蕾1 刘烈炬1 刘长金1 
单位:1.华中科技大学同济医学院,生理学系,湖北,武汉,430030; 2.安庆市立医院,安徽,安庆,246000
关键词:背根神经节小细胞 缺氧 电压门控钾通道 全细胞膜片钳 
分类号:R33-33, Q952.5
出版年·卷·期(页码):2008·27·第四期(233-237)
摘要:

目的:探讨氧感受过程参与对钾通道调制的假设.方法:应用新鲜分离的小鼠背根神经节小细胞,采用全细胞膜片钳记录IK电流.结果:当小细胞缺氧时,钾通道在3 min之内即可发生变化,表现为绝大多数(86%, 6/7)细胞的IK减弱,1个细胞(14%,1/7)的IK电流增强;缺氧1 min时IK减弱,3 min时产生最大抑制.当测试电位从+10 mV至+70 mV时,急性缺氧显著性降低IK,IK电流密度降低最大幅度从(304.4±122.9)降为(253.9±106.4)pA·pF-1,但IK稳态激活曲线无明显变化.结论:急性缺氧抑制小鼠背根神经节小细胞IK电流,而IK电流的抑制作用可能是外周神经细胞对缺氧的一种适应和保护机制.

参考文献:

[1] OCANA M, CEVDAN C M, COBOS E J. Potassium channels and pain:present realities and future opportunities. 2004(1/3). doi:10.1016/j.ejphar.2004.07.026
[2] LIU L, SIMON S A. Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 2003(3). doi:10.1152/jn.00210.2002
[3] YOST C S. Potassium channels:basic aspects,functional roles,and medical significance. 1999. doi:10.1097/00000542-199904000-00035
[4] GAO L L, SONG Y L, TANG M. Effect of hypoxia on hyperpolarization-activated current in mouse dorsal root ganglion neurons. 2006(1). doi:10.1016/j.brainres.2006.01.037
[5] URBAN L, SOMJEN G G. Reversible effects of hypoxia on neurons in mouse dorsal root ganglia in vitro. 1990(1-2). doi:10.1016/0006-8993(90)91689-E
[6] UTZSCHNEIDER D A, KOCSIS J D. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. 1991(1-2). doi:10.1016/0006-8993(91)90924-K
[7] MOGYOROS I, KIERNAN M C, BURKE D. Excitability changes in human sensory and motor axons during hyperventilation and ischaemia. 1997. doi:10.1093/brain/120.2.317
[8] HENRICH M, HOFFMANN K, KONIG P. Sensory neurons respond to hypoxia with NO production associated with mitochondria. 2002(2). doi:10.1006/mcne.2002.1111
[9] GRUSS M, HENRICH M, KONIG P. Ethanol reduces excitability in a subgroup of primary sensory neurones by activation of BKCa channels. 2001(8). doi:10.1046/j.0953-816x.2001.01754.x
[10] ISHIKAWA K, TANAKA M, BLACK J A. Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy. 1999(4). doi:10.1002/(SICI)1097-4598(199904)22:4&lt, 502::AID-MUS12&gt, 3.0.CO, 2-K

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