血尿酸与2型糖尿病胰岛素抵抗及血管并发症的关系-东南大学学报医学版

血尿酸与2型糖尿病胰岛素抵抗及血管并发症的关系

单位：无锡市惠山区人民医院,内分泌科,江苏,无锡,214187

分类号：R587.2, R589.7

出版年·卷·期（页码）：2008·27·第三期（223-225）

摘要：

目的:评价高尿酸血症对2型糖尿病胰岛素抵抗及血管并发症的影响,并探讨其可能的发生机制.方法:68例2型糖尿病患者,根据血尿酸水平分成尿酸正常(NUA)组(42例)和高尿酸(HUA)组(26例),分析两组病人的胰岛素抵抗指数和大血管、微血管病变发生率的差异.结果:(1)HUA组体重指数(BMI)、甘油三酯(TG)、血压(BP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、腰臀比值(WHR)、胰岛素抵抗指数(HOMA-IR)均高于NUA组(均P<0.05),而高密度脂蛋白胆固醇(HDL-C)则低于NUA组(P<0.05).(2)HUA组冠心病、脑血管病、视网膜病变、肾脏病变、颈动脉斑块和下肢动脉斑块的发生率均高于NUA组(均P<0.05).结论: 高尿酸血症与肥胖、血脂异常、胰岛素抵抗明显相关,并可导致大血管及微血管并发症的发生.

Objective To evaluate the effect of hyperuricemia on insulin resistance and vascular complications of type 2 diabetes and to analyze the possible mechanism.Methods 68 cases with type 2 diabetes were divided into two groups:normal serum uric acid(n=42) and hyperuricemia(n=26).The insulin resistance index and macrovascular and microvascular complications were detected.Results(1)Hyperuricemia group showed higher body mass index(BMI),blood pressure(BP),TG,TC,LDL,waist-hip ratio(WHR),hemeostasis model assessment-insulin resistance(HOMA-IR) ratio and lower serun HDL-C than the group with normal serum uric acid(all P<0.05).(2)Higher morbidities due to macrovascular and microvascular complications were found in the group with hyperuricemia than in the group with normal serum uric acid(all P<0.05).Conclusions Hyperuricemia is associated with obesity and dyslipidmia and insulin resistance,resulting in macrovascular and microvascular complications.

参考文献：

[1] 廖二元, 超楚生. 内分泌学, 2004
[2] 朱煜, 唐汇敏, 邓江平. 原发性高尿酸血症患病率调查. 东南大学学报(医学版)2007(1). doi:10.3969/j.issn.1671-6264.2007.01.014
[3] NISKANEN L, LAAKSONEN D E, LINDSTRON J. Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance. 2006. doi:10.2337/diacare.29.03.06.dc05-1465
[4] 雒瑢, 樊继援. 血尿酸与2型糖尿病及并发冠心病的关系. 中国糖尿病杂志2006(1)
[5] PUDDU P E, LANTI M, MENOTTI A. Serum uric acid for short-term prediction of cardiovascular disease incidence in the Gubbio population study. 2001(4). doi:10.2143/AC.56.4.2005651

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