Objective To explore the pathological and morphological features,pathological diagnosis,differential diagnosis,therapy and prognosis of the spiradenoma(SA).Methods Eight cases of the spiradenoma were studied by using paraffin slice for HE staining and immunohischemistrical method(EnVision method).Results 8 patients aged from 28 to 66 years,averaging 40.1 years old,4 cases of each genda,showed small nodules beneath skin accompanied with pain.The size of nodules ranged from 0.3 cm to 1.5 cm.Under microscope,two distinct types of neoplasm epithelial cells could be seen,namely,the dark cells and the pale cells.The dark cells were basaloid cells and located at the periphery of the neoplasm cell nests,whereas,the pale cells were glandular epithelia cells and tended to situate in the center of the nests.Two of the 8 cases were followed-up for 2-3 years.No evidence of recurrence was found for the two cases.Conclusions Spiradenoma usually appeared as a solitary nodule with tenderness and located deeply in cutis at any region of the body.Spiradenoma is commonly benign.By immunochemistry stain,the basaloid cells are myoepithelium markers positive,and the glandular epithelia cells are glandular epithelium markers positive. |
