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乳腺癌新辅助化疗的研究进展
作者:李丽1  张亚男2  尤承忠2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 普外三科, 江苏 南京 210009
关键词:乳腺癌 新辅助化疗 研究进展 文献综述 
分类号:R737.9;R453
出版年·卷·期(页码):2013·32·第六期(766-771)
摘要:

作者分别从乳腺癌新辅助化疗的定义、临床意义、不良反应、预后指标、疗效及其评价、与前哨淋巴结的关系和存在的问题等方面对乳腺癌新辅助化疗的研究进展作一综述,认为新辅助化疗是乳腺癌全身治疗重要的部分,但在如何选择药物、制订方案、预测效果等方面仍需进一步研究。

参考文献:

[1] FISHER B,BRYANT J,WOLMARK N,et al.Effect of preoperative chemotherapy on the outcome of women with operable breast cancer[J].J Clin Oncol,1998,16(8):2672-2685.
[2] MAURIAC L,MacGROGAN G,AVRIL A,et al.Neoadjuvant chemotherapy for operable breast carcinoma larger than 3 cm:a unicentre randomized trial with a 124-month median follow-up[J].Ann Oncol,1999,10(1):47-52.
[3] BROËT P,SCHOLL S M,de la ROCHEFORDIERE A,et al.Short and long-term effects on survival in breast cancer patients treated by primary chemotherapy:an updated analysis of a randomized trial[J].Breast Cancer Res Treat,1999,58(2):151-156.
[4] BONADONNA G,VALAGUSSA P,BRAMBILLA C,et al.Primary chemotherapy in operable breast cancer:eight-year experience at the Milan Cancer Institute[J].J Clin Oncol,1998,16(1):93-100.
[5] van der HAGE J A,van de VELDE C J H,JULIEN J P,et al.Preoperative chemotherapy in primary operable breast cancer:results from the European Organization for Research and Treatment of Cancer trial 10902[J].J Clin Oncol,2001,19(22):4224-4237.
[6] BONADONNA G,VERONESI U,BRAMBILLA C,et al.Primary chemotherapy to avoid mastectomy in tumors with diameters of three centimeters or more[J].J Nat Cancer Inst,1990,82(19):1539-1545.
[7] GIANNI L,BASELGA J,EIERMANN W,et al.Phase Ⅲ trial evaluating the addition of paclitaxel to doxorubicin followed by cyclophosphamide,methotrexate,and fluorouracil,as adjuvant or primary systemic therapy:European Cooperative Trial in Operable Breast Cancer[J].J Clin Oncol,2009,27(15):2474-2481.
[8] 李卉,廖传贵,何小梅.晚期乳腺癌新辅助化疗的临床报告[J].中国普外基础与临床杂志,2004,11(1):20-21.
[9] BHALLA K,HARRIS W B.Molecular and biologic determinants of neoadjuvant chemotherapy of locoregional breast cancer[C]//Seminars in oncology.Elsevier,1998,25(2):19-24.
[10] RASTOGI P,ANDERSON S J,BEAR H D,et al.Preoperative chemotherapy:updates of national surgical adjuvant breast and bowel project protocols B-18 and B-27[J].J Clin Oncol,2008,26(5):778-785.
[11] MALAMOS N,KOSMAS C,ANTONOPOULOS M J,et al.Prospective randomized study of neoadjuvant chemotherapy (NACT) with paclitaxel/epirubicin (PE) versus fluorouracil/epirubicin/cyclophosphamide (FEC) in operable stage Ⅱ-ⅢA breast cancer (BC)[C]//Annals of Oncology.Spuiboulevard 50,PO BOX 17,3300 AA DORDRECHT,NETHERLANDS:KLUWER ACADEMIC PUBL,1998,9:22-23.
[12] BEAR H D,ANDERSON S,BROWN A,et al.The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide:preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27[J].J Clin Oncol,2003,21(22):4165-4174.
[13] LUPORSI E,VANLEMMENS L,COUDERT B,et al.Cycles of FEC 100 vs 6 cycles of epirubicin-docetaxel (ED) as neoadjuvant chemotherapy in operable breast cancer patients (pts):preliminary results of a randomized phase Ⅱ trial of GIREC S01[C]//Proc Am Soc Clin Oncol,2000,19:92a.
[14] STEGER G G,GALID A,GNANT M,et al.Pathologic complete response with six compared with three cycles of neoadjuvant epirubicin plus docetaxel and granulocyte colony-stimulating factor in operable breast cancer:results of ABCSG-14[J].J Clin Oncol,2007,25(15):2012-2018.
[15] VINCENT-SALOMON A,ROUSSEAU A,JOUVE M,et al.Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy[J].Eur J Cancer,2004,40(10):1502-1508.
[16] BOTTINI A,BERRUTI A,BERSIGA A,et al.Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer[J].Br J Cancer,2001,85(8):1106-1112.
[17] PETIT T,WILT M,VELTEN M,et al.Comparative value of tumour grade,hormonal receptors,Ki-67,HER-2 and topoisomerase Ⅱ alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy[J].Eur J Cancer,2004,40(2):205-211.
[18] FANEYTE I F,SCHRAMA J G,PETERSE J L,et al.Breast cancer response to neoadjuvant chemotherapy:predictive markers and relation with outcome[J].Br J Cancer,2003,88(3):406-412.
[19] 谢菲,周波,曹迎明,等.不同生物学标志物对乳腺癌新辅助化疗疗效的预测价值[J].中国癌症杂志,2010,20(6):452-456.
[20] ESTVEZ L G,CUEVAS J M,ANTÓN A,et al.Weekly docetaxel as neoadjuvant chemotherapy for stage Ⅱ and Ⅲ breast cancer efficacy and correlation with biological markers in a phase Ⅱ.Multicenter Study[J].Clin Cancer Res,2003,9(2):686-692.
[21] 胡波飞,贾明,魏素菊.Ki-67 与传统生物学标志物预测乳腺癌化疗药物敏感性的研究进展[J].现代肿瘤医学,2012,20(4):853-856.
[22] COLLEONI M,VIALE G,ZAHRIEH D,et al.Expression of ER,PgR,HER1,HER2,and response:a study of preoperative chemotherapy[J].Annals of oncology,2008,19(3):465-472.
[23] GUARNERI V,BROGLIO K,KAU S W,et al.Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors[J].J Clin Oncol,2006,24(7):1037-1044.
[24] JONES R L,SALTER J,A'HERN R,et al.Relationship between oestrogen receptor status and proliferation in predicting response and long-term outcome to neoadjuvant chemotherapy for breast cancer[J].Breast Cancer Res Treat,2010,119(2):315-323.
[25] OGSTON K N,MILLER I D,SCHOFIELD A C,et al.Can patients' likelihood of benefiting from primary chemotherapy for breast cancer be predicted before commencement of treatment?[J].Breast Cancer Res Treat,2004,86(2):181-189.
[26] 韩芸蔚,温绍艳,刘伟,等.乳腺癌新辅助化疗的临床评价方法解析[J].中国肿瘤临床,2011,38(7):415-418.
[27] 吴艳艳,彭玉兰.乳腺癌新辅助化疗的影像学评价[J].临床超声医学杂志,2010,12(4):258-261.
[28] TOZAKI M,UNO S,KOBAYASHI T,et al.Histologic breast cancer extent after neoadjuvant chemotherapy:comparison with multidetector-row CT and dynamic MRI[J].Radiat Med,2003,22(4):246-253.
[29] IZZO L,STASOLLA A,BASSO L,et al.Characterization of tumoral lesions of the breast:preliminary experience with multislice spiral CT[J].J Exp Clin Cancer Res,2005,24(2):209-214.
[30] NASON K S,ANDERSON B O,BYRD D R,et al.Increased false negative sentinel node biopsy rates after preoperative chemotherapy for invasive breast carcinoma[J].Cancer,2000,89(11):2187-2194.
[31] BRESLIN T M,COHEN L,SAHIN A,et al.Sentinel lymph node biopsy is accurate after neoadjuvant chemotherapy for breast cancer[J].J Clin Oncol,2000,18(20):3480-3486.
[32] TACCA O,PENAULT-LIORCA F,ABRIAL C,et al.Changes in and prognostic value of hormone receptor status in a series of operable breast cancer patients treated with neoadjuvant chemotherapy[J].Oncologist,2007,12(6):636-643.
[33] 蒋文英,桑剑锋,苏磊,等.乳腺癌新辅助化疗疗效及其判断方法[J].现代医学,2011,39(2):237-240.
[34] 单海琳,李俊生,邵清.乳腺癌组织中 ADAM8 mRNA 的表达及意义[J].南大学学报:医学版,2011,30(6):822-826.

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