Objective: To explore the relationship between nonalcoholic fatty liver disease fibrosis score (NAFLD fibrosis score) and central obesity and insulin resistance (IR). Methods: A total of 2 891 subjects from Medical Examination Center of Central Hospital of Xuzhou were included in the study. All of the subjects' blood test were collected to calculate NAFLD fibrosis score. IR was calculated by the homeostasis model (HOMA-IR), which was equal to fasting insulin (mU·L-1)×fasting glucose (mmol·L-1)/22.5. Subjects were divided by whether they are suffering the pathema:A1(non-central obesity), A2(central obesity); B1(non-IR), B2(IR). Results: Neck circumference, waist circumference, hip circumference, WHR, WBC, neutrophile granulocyte,weight, HbA1c were associated with the NAFLD fibrosis score. Among M1, M2 and M3, the nosometry of central obesity was significantly different (P<0.001) and increases with the score, IR was the same (P<0.001). Conclusion: NAFLD fibrosis score constructed from routine clinical and laboratory variables is associated with the prevalence rate of central obesity and IR, it is a useful clinical practical evaluation index of IR. |
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