[1] 吕文超,崔云甫.胰腺癌流行病学和病因学研究进展[J].世界华人消化杂志.2011;19(27):2805-2809.
[2] APTE M V,WILSON J S.Dangerous liaisons:pancreatic stellate cells and pancreatic cancer cells[J].Gastroenterol Hepatol,2012,2:69-74.
[3] BACHEM M G,SCHNEIDER E,CROSS H,et al.Identification,culture,and characterization of pancreatic stellate cells in rats and humans[J].Gastroenterology,1998,115(2):421-432.
[4] BACHEM M G,ZHOU S,BUCK K,et al.Pancreatic stellate cells-role in pancreatic cancer[J].Langenbecks Arch Surg,2008,396(6):891-900.
[5] TSANG K Y,CHEUNG M C,CHAN D,et al.The developmental roles of the extracellular matrix:beyond structure to regulation[J].Cell Tissue Res,2010,339:93-110.
[6] JARVELAINEN H,SAINIO A,KOULU M,et al.Extracellular matrix molecules:potential targets in pharmacotherapy[J].Pharmacol Rev,2009,61:198-223.
[7] KORC M.Pancreatic cancer associated stroma production[J].Am J Surg,2007,194(4):s84-s86.
[8] ERKAN M,MICHALSKI C W,RIEDER S,et al.The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma[J].Clin Gastroenterol Hepatol,2008,6:1155-1161.
[9] FUJITA H,OHUCHIDA K,MIZUMOTO K,et al.Tumor-stromal interactions with direct cell contacts enhance proliferation of human pancreatic carcinoma cells[J].Cancer Sci,2009,100:2309-2317.
[10] BAILEY J M,SWANSON B J,HAMADA T,et al.Sonic hedgehog promotes desmoplasia in pancreatic cancer[J].Clin Cancer Res,2008,14:5995-6004.
[11] LOGSDON C D,SIMEONE D M,BINKLEY C,et al.Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer[J].Cancer Res,2003,63(10):2649-2657.
[12] HAMADA S,MASAMUNE A,TAKIKAWA T,et al.Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells[J].Biochem Biophys Res Commun,2012,421(2):349-354.
[13] LANGLEY R R,FIDLER I J.Review Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis[J].Endocr Rev,2007,28(3):297-321.
[14] VONLAUFEN A,JOSHI S,QU C,et al.Pancreatic stellate cells:partners in crime with pancreatic cancer cells[J].Cancer Res,2008,68(7):2085-2093.
[15] DUNCAN T J,Al-ATTAR A,ROLLAND P,et al.Vascular endothelial growth factor expression in ovarian cancer:a model for targeted use of novel therapies?[J].Clin Cancer Res,2008,14(10):3030-3035.
[16] MASAMUNE A,KIKUTA K,WATANABE T,et al.Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer[J].Am J Physiol Gastrointest Liver Physiol,2008,295(4):G709-G717.
[17] KIKUTA K,MASAMUNE A,WATANABE T,et al.Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells[J].Biochem Biophys Res Commun,2010,403:380-384.
[18] SCHNEIDERHAN W,DIAZ F,FUNDEL M,et al.Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay[J].J Cell Sci,2007,120:512-519.
[19] ZHOU Y,ZHOU Q,CHEN R.Pancreatic stellate cells promotes the perineural invasion in pancreatic cancer[J].Med Hypotheses,2012,78(6):811-813.
[20] HWANG R F,MOORE T,ARUMUGAM T,et al.Cancer associated stromal fibroblasts promote pancreatic tumor prog ression[J].Cancer Res,2008,68:918-926.
[21] NETTI P A,BERK D A,SWARTZ M A,et al.Role of extracellular matrix assembly ininterstitial transport in solid tumors[J].Cancer Res,2000,60:2497-2503.
[22] MATTHAIOS D,ZAROGOULIDIS P,BALGOURANIDOU L,et al.Molecular pathogenesis of pancreatic cancer and clinical perspectives[J].Oncology,2011,81(3-4):259-272.
[23] SCHWER C I,GUERRERO A M,HUMAR M,et al.Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the extracellular signal-regulated kinase1/2 pathway[J].J Pharmacol Exp Ther,2008,327(3):863-871.
[24] ROY S K,SRIVASTAVA R K,SHANKAR S.Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor,leading to cell cycle arrest and apoptosis in pancreatic cancer[J].J Mol Signal,2010,5:10.
[25] NISHIDA A,ANDOH A,SHIOYA M,et al.Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-32alpha induction in human pancreatic periacinar myofibroblasts[J].Am J Physiol Gastrointest Liver Physiol,2008,294:831-838.
[26] SCHWER C I,STOLL P,ROSPERT S,et al.Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2[J].Int J Biochem Cell Biol,2013,45(2):201-212.
[27] MASAMUNE A,SATOH M,KIKUTA K,et al.Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic[J].World J Gastroenterol,2005,11(22):3385-3391.
[28] FERRAND A,KOWALSKI-CHAUVEL A,BERTRAND C,et al.A novel mechanism for JAK2 activation by a G protein-coupled receptor,the CCK2R:implication of this signaling pathway in pancreatic tumor models[J].J Biol Chem,2005,280:10710-10715.
[29] YU J H,KIM H.Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer[J].Gut Liver,2012,6(4):417-422.
[30] JOOST S,ALMADA L L,ROHNALTER V,et al.GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells[J].Cancer Res,2012,72(1):88-99.
[31] BAILEY J M,SWANSON B J,HAMADA T,et al.Sonic hedgehog promotes desmoplasia in pancreatic cancer[J].Clin Cancer Res,2008,4(19):5995-6004.
[32] SHINOZAKI S,OHNISHI H,HAMA K,et al.Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane[J].Cell Physiol,2008,216:38-46.
[33] MASAMUNE A,SHIMOSEGAWA T.Review signal transduction in pancreatic stellate cells[J].J Gastroenterol,2009,44(4):249-260. |
