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抗细胞老化治疗椎间盘退变性病变的研究进展
作者:曹鹏飞  吴小涛  王运涛 
单位:东南大学附属中大医院骨科, 江苏 南京 210009
关键词:细胞老化 椎间盘退变 治疗 文献综述 
分类号:R681.53
出版年·卷·期(页码):2013·32·第四期(479-482)
摘要:

细胞老化在椎间盘退变过程中起到了重要的促进作用。细胞老化在椎间盘退变中的机制主要分为两类:一类是p53-p21-pRb信号介导的复制老化,另一类是p16-pRb途径介导的应激诱导早衰。这两种机制为治疗椎间盘退变疾病带来了新的思路。现有抗细胞老化的主要策略是抗复制老化、抗应激诱导早衰以及逆转老化信号介导途径延缓细胞老化和细胞移植。作者对以上几个方面的最新研究进展做一综述。

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