目的: 通过Meta分析探讨干细胞移植对肝硬化失代偿期的治疗作用。方法: 计算机联合检索中国生物医学文献数据库、万方数据库、CNKI、 PUBMED、EMBASE、Cochrane图书馆、SSCI、VIP获得相关文献,检索时间从建库到2012年5月。对同质研究用RevMan 4.2软件进行Meta分析。结果: 经过排除和筛选,共纳入7篇随机对照实验用于临床评价,共617例患者。干细胞移植术后1、2、3个月肝硬化患者的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、凝血酶原时间(PT)均较术前有显著下降,血清白蛋白水平(ALB)较术前有显著提高,术后2个月总胆红素(TB)较术前有显著下降,差异均有统计学意义。结论: 骨髓干细胞移植后,患者肝功能改善明显。 |
Objective: To evaluate the treatment effect of stem cell transplantion for liver cirrhosis by Meta-analysis. Methods: The Cochrance Central Register of Controlled Trials,CBM,CNKI,PUBMED,EMBASE,SSCI,VIP were researched dated up to May 2012.Meta-analysis was performed for homogeneous studies with RevMan 4.2 software. Results: A total of 7 studies carried out by randomization method including 617 patients. we could see the significant decline on the results of ALT,AST,PT obtained from the patients of liver cirrhosis who accepted the stem cell transplantation at 1,2,3 month post operation respectively and the decline on the result of TB at 2 month post operation.Meantime,the result of ALB increased dramatically as well.All the difference was statistically significant. Conclusion: Stem cell transplantation can significantly improve the liver function of patients with good safety and effectiveness. |
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