慢性荨麻疹患者血清中特异性IgE和IgG检测的临床应用-东南大学学报医学版

慢性荨麻疹患者血清中特异性IgE和IgG检测的临床应用

作者：何君邢艳

单位：南京市职业病防治院检验科, 江苏南京 210042

分类号：R758.24

出版年·卷·期（页码）：2013·32·第四期（417-421）

摘要：

目的: 探讨慢性荨麻疹患者血清特异性IgE(sIgE)和特异性IgG(sIgG)检测的意义及其在临床中的应用。方法: 对593例慢性荨麻疹患者采用免疫印迹法检测血清中食物过敏原和吸入性过敏原sIgE,同时采用酶联免疫法检测血清中食物sIgG,并在不同年龄组间进行比较。结果: 593例慢性荨麻疹患者食物sIgG的总阳性率为76.73%,前4位的食物依次是鸡蛋、牛奶、蟹和大豆。食物sIgE的总阳性率为54.13%,前4位的食物依次是蟹、虾、牛奶和腰果;食物sIgG和sIgE的检测结果不一致(P<0.01)。不同年龄组的过敏原检测结果有所不同,吸入性过敏原sIgE的总阳性率为89.38%,前3位依次均是户尘螨、矮豚草、霉菌组合。结论: 联合测定患者血清中sIgE和sIgG是寻找慢性荨麻疹患者过敏原的有效方法。尽早采取有效的环境控制和食物规避,对预防和治疗急性荨麻疹及慢性荨麻疹急性发作相当重要。

Objective: To investigate the significance of sIgE and sIgG detection and their clinical application in chronic urticaria serum patients. Methods: 593 cases of chronic urticaria patients were recruited in this study. The food and inhalant sIgE were detected using immunoblot assay from serum of chronic urticaria patients, while enzyme-linked immunosorbent assay was applied for sIgG detection. The results in different age groups were compared. Results: The positive rate of ingested sIgG in 593 patients was 76.73%, the top four food was eggs, milk, crab and soybean. The ingested sIgE positive rate was 54.13%, and the top four food was crab, shrimp, milk and cashew nuts. Food sIgG and sIgE test results were significantly different(P<0.01). The anaphylactogen in different age groups was not the same. The total positive rate of inhalation of allergen sIgE was 89.38%, the top three was dermatophagoides pteronyssinus, dwarf ragweed, and mold combination. Conclusion: The combined determination of serum sIgE and sIgG is the best effective method to look for allergen in chronic urticaria patients. It is important to control the environment and food for the prevention and treatment of acute urticaria and acute attack of chronic urticaria.

参考文献：

[1] 方莉,毕永春,胡伟,等.260例变态反应性皮肤病患者血清过敏原的检测和分析[J].现代医学,2012,40(1):71-73.
[2] 卢肖霞,黄卫宁,熊春萍,等.慢性荨麻疹与食物不耐受血清特异性IgG的相关性分析[J].实验与检验医学,2011,29(4):357-359.
[3] 刘晓依,陈戟.257例儿童荨麻疹血清特异性过敏原IgE检测结果分析[J].临床皮肤科杂志,2011,40(12):722-724.
[4] IRENE L C, ALEXANDRA B M, ELENA P I. Chronic urticaria in children[J]. Clinical Pediatrics, 2009, 48(4):351-355.
[5] ODOM R R, JAMESW D, BERGER T G.安德鲁斯皮肤病学[M].9版.北京:科学技术出版社,2001:160-161.
[6] 张学军.皮肤性病学[M].7 版.北京:人民卫生出版社, 2009:115.
[7] 彭少文,宋克敏,敖俊红,等.北京地区慢性荨麻疹阿罗格皮肤点刺试验变应原检测分析[J].实用皮肤病学杂志,2008,1(3):139-141.
[8] 匡国珍,刘志军,段明.衡阳地区荨麻疹和湿疹患者过敏原检测分析[J].南华大学学报:医学版,2010,38(2):236-238.
[9] SAMPSON H A. Update of food allergy[J].J Allergy Clin Immunol,2004,113(5):805-819.
[10] 邵洁.儿童食物过敏与急性过敏反应[J].临床儿科杂志,2008,26(1):附1-附3.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录