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可溶性晚期糖基化终产物受体基础与临床研究新进展
作者:沈潇  刘乃丰 
单位:东南大学医学院, 江苏 南京 210009
关键词:可溶性晚期糖基化终产物受体 晚期糖基化终产物受体 生物标志物 动脉粥样硬化 综述 
分类号:Q513.2;R54
出版年·卷·期(页码):2013·32·第三期(364-369)
摘要:

晚期糖基化终产物受体(receptor for advanced glycation end-products,RAGE)是晚期糖基化终产物(advanced glycation end products,AGEs)最具特征的受体之一,通过与AGEs的结合,可促进炎症反应并参与多种病理过程。可溶性RAGE(soluble forms of RAGE,sRAGE)是RAGE的可溶性形式,可阻止RAGE与其相关的促炎配体(AGEs,高流变簇盒蛋白1,S100蛋白质)结合。目前越来越多的研究发现sRAGE可作为生物标志物或者内源性蛋白因子阻止RAGE介导的疾病发生,表明sRAGE在众多疾病的发生发展中有着举足轻重的作用。鉴于此,作者主要对sRAGE在相关疾病(例如心血管疾病、糖尿病、高胆固醇血症、慢性肾脏病、免疫/炎症性疾病等)基础与临床研究中的进展进行综述。

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