益气活血方联用奥美拉唑对大鼠消化性溃疡愈合质量的影响-东南大学学报医学版

益气活血方联用奥美拉唑对大鼠消化性溃疡愈合质量的影响

单位：苏州市中医医院中医药研究所, 江苏苏州 215003

分类号：R289.51;R573.1

出版年·卷·期（页码）：2013·32·第三期（320-323）

摘要：

目的:探讨益气活血方联用奥美拉唑治疗对溃疡愈合质量的影响。方法:建立乙酸性大鼠胃溃疡模型,将96只成模大鼠随机分为模型组、奥美拉唑组、益气活血方组和奥美拉唑+益气活血方组4组,每日灌胃分别饲以蒸馏水和不同药物,连续14或21或28d后取溃疡胃组织。评估再生黏膜组织成熟度,以判定溃疡愈合质量。结果:经益气活血方联用奥美拉唑治疗后,大鼠再生黏膜厚度增加,囊状扩张腺体数目减少,肉芽组织炎症细胞浸润数量减少,微血管数量增加,黏膜损伤程度下降,明显优于奥美拉唑单药治疗组。结论:益气活血方联用奥美拉唑治疗,能提高再生黏膜组织成熟度,从而提高溃疡愈合质量。

Objective: To investigate the effect of Yiqihuoxue decoration(YQHXF) combined with omeprazole(OMLZ)on quality of ulcer healing(QOUH).Methods: To establish gastric ulcer models in rats,Ninty-six SD rats were randomly divided into four groups,mode group,OMLZ group,YQHXF group,YQHXF+OMLZ group,every groups were operated and treated with distilled water,OMLZ and YQHXF respectively.After 14 or 21 or 28 days of treatment,the tissue was obtained and measured. Results: YQHXF + OMLZ group compared with OMLZ group,the regenerative gastric mucosa had significantly thinned,but the number of cystic-dilated glands,inflammatory cells and capillary vessel were obviously increased. Conclusion: Yiqihuoxue Decoration combined with omeprazole could ameliorate the regenerative mucosal structure of gastric ulcer and improve QOUH.

参考文献：

[1] 匡思祯,曾贤斌.消化性溃疡复发原因及治疗现状[J].中国现代实用性杂志,2007,1(1):32-34.
[2] 韦强,翟俊山.消化性溃疡临床治疗分析[J].现代医学,2010,38(1):72-73.
[3] 张卫平,葛惠男.益气活血方对消化性溃疡愈合质量影响的临床研究[J].湖北中医杂志,2008,30(6):123-125.
[4] 张卫平,葛惠男.益气活血方对溃疡愈合质量及血清VEGF、bFGF影响的临床研究[J].中国中医急症,2009,12(8):1239-1241.
[5] 张卫平,葛惠男.益气活血方对消化性溃疡愈合质量及复发的影响[J].中国中西医结合杂志,2009,29(12):1081-1084.
[6] 彭琳,张志明,梁小梅.消化性溃疡159例发病相关因素调查分析[J].现代医学,2002,30(6):410-411.
[7] OKABE S,ROTH J L A,PFEIFFER C J.A method for experimental,penetrating gastric and duodenal ulcer in rats[J].AM J Dig Dis,1971,16(3):277-284.
[8] 徐叔云,卞如濂,陈修.药理实验方法学[M].北京:人民卫生出版社,2002:1332.
[9] 梅武轩,曾常春.乳香提取物对大鼠乙酸胃溃疡愈合质量的影响[J].中国中西医结合消化杂志,2004,12(1):34-36.
[10] 姒健敏,钱云,吴加国.云母对实验性胃溃疡愈合质量的影响[J].中国中药杂志,2005,30(19):1536-1541.
[11] 姒健敏.消化性溃疡的愈合质量[J].中华消化杂志,2005,25(2):127-1281.
[12] TARNAWSKI A.Quality of ulcer healing:a new emerging concept[J].J Clin Gastroenterol,1991,13(suppl 1):S42-S47.

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