MAOA-uVNTR多态性与学步期儿童内隐问题行为的关系-东南大学学报医学版

MAOA-uVNTR多态性与学步期儿童内隐问题行为的关系

作者：汪志鹏¹ 2 刘亚鹏¹ 张明浩¹ 3 陈平¹ 张光珍¹ 梁宗保¹ 邓慧华¹ 陆祖宏¹ 2

单位：1. 东南大学学习科学研究中心, 江苏南京 210096;
2. 东南大学生物科学与医学工程学院, 江苏南京 210096;
3. 鲁东大学心理学院, 山东烟台 264000

分类号：R174;R395.2

出版年·卷·期（页码）：2013·32·第三期（293-296）

摘要：

目的:探究MAOA基因重复片段多态性对学步期儿童内隐问题行为的影响。方法:以295名学步期儿童为研究对象,在儿童6个月时,采集口腔脱落细胞,24个月时由父母报告其内隐问题行为。结果:拥有3型MAOA基因的男孩抑郁、焦虑以及内隐问题行为的水平与4型男孩的水平相比较差异无统计学意义(P>0.05);拥有4/4 型MAOA基因的女孩,其抑郁、焦虑以及内隐问题行为的水平与3/3+3/4型女孩差异无统计学意义(P>0.05)。结论:这表明MAOA-uVNTR多态性对学步期儿童抑郁、焦虑以及内隐问题行为均没有显著影响。

Objective: Toddler's internalizing problem behaviors is one of the important results of children's socialization.It will give rise to the negative effect on children's learning,psychological health and personality development.This study aims to investigate the effects of MAOA-uVNTR polymorphism on internalizing problem behaviors of 295 toddlers. Methods: When toddlers aged 6 months,their cheek cells were collected and their internalizing problem behaviors were reported by their parents at the age of 24 months. Results: It was found that boys with 3 genotypes don't differ in the level of depression,anxiety and internalizing problem behaviors from that of boys with 4 genotypes significantly.The level of depression,anxiety and internalizing problem behaviors of girls with 3/3 and 3/4 genotypes shows no difference with that of girls with 4/4 genotypes. Conclusion: These results suggest that MAOA-uVNTR polymorphism do not play a role in boy's or girl's depression,anxiety and internalizing problem behaviors.

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