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mTOR信号通路与大肠癌演进相关性的研究进展
作者:常立功  黄培林 
单位:东南大学医学院 病理学与病理生理学系,江苏 南京 210009
关键词:雷帕霉素靶蛋白 信号通路 大肠癌 文献综述 
分类号:R735.34;R730.2
出版年·卷·期(页码):2013·32·第二期(243-247)
摘要:

哺乳动物雷帕霉素靶蛋白(mTOR)信号通路是由一系列蛋白分子组成的细胞内最重要的信号传导途径之一,其结构复杂,具体功能尚未明了。近年来,随着对大肠癌发病机制研究的深入,人们逐渐认识到mTOR信号通路在大肠癌发生发展中起重要作用,mTOR通路的过度激活可促进大肠癌的恶性表型与转移。因此,了解mTOR信号通路在大肠癌演进过程中的作用对指导临床大肠癌的诊疗大有裨益。

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