目的:探讨老年Ⅰ期非小细胞肺癌(NSCLC)体部立体定向放疗(SBRT)的近期疗效及安全性。方法:回顾性分析经SBRT治疗的5例老年Ⅰ期周围性NSCLC患者,给予肿瘤病灶50 Gy/5 F,95％以上剂量线覆盖PTV50的靶区范围,分别于放疗结束后1个月和3个月复查胸部CT,观察近期疗效,并评价急性放疗反应。结果:放疗结束后1个月复查评价疗效,1例完全缓解(CR),4例部分缓解(PR),放疗结束后3个月评价疗效,4例达CR,1例PR,有效率达100%,生活质量也明显改善,没有发现可评价的急性放射性肺炎表现及骨髓抑制。5例患者中皮肤反应均为1级。结论:SBRT治疗老年Ⅰ期NSCLC是一种安全、有效的治疗手段。 |
Objective: To assess early efficacy and safety of stereotactic body radiotherapy(SBRT) in elderly patients with stage Ⅰ non-small cell lung cancer. Methods:Five elderly patients with peripheral stage Ⅰ non-small cell lung cancer were retrospectively analysed. All of the five patients accepted SBRT, tumor range accepted 50 Gy/5 F, the line above 95% coverage the target range of PTV50. Chest CT was assessed one month and three months after radiotherapy respectively, early efficacy was observed,and the acute radiation reaction was evaluated. Results: Five patients had CT scan, 1 month after radiotherapy,one case reached CR, other 4 cases PR, 3 months later 4 cases were CR, only one was PR, the effective rate was 100%, quality of life was also improved significantly.It found no performance evaluation of acute radiation pneumonitis and bone marrow suppression. Skin reactions of 5 patients were Ⅰ. Conclusion: For elderly patients with stage Ⅰ non-small cell lung cancer, SBRT is a safe, effective treatment. |
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