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激肽释放酶-激肽系统在缺血损伤后血管新生中的作用研究进展
作者:傅聪  姚玉宇 
单位:东南大学医学院 心血管病研究所; 东南大学附属中大医院 心血管内科, 江苏 南京 210009
关键词:激肽释放酶-激肽系统 缺血损伤 血管新生 文献综述 
分类号:R5
出版年·卷·期(页码):2012·31·第六期(756-760)
摘要:

激肽释放酶-激肽系统主要由激肽原、激肽释放酶和激肽组成, 该系统在心肌梗死和缺血损伤后血管新生中发挥重要作用。激肽及其受体B1和B2在急性心肌梗死后发挥保护作用,并能促进缺血下肢的血管新生过程。高分子量激肽原的水解产物HKa在血管新生过程中发挥负性调节作用,抑制内皮细胞的增殖和黏附,诱导其发生凋亡。此外,激肽及其受体B1和B2在新生血管形成中发挥一系列的正性调节作用,促进内皮祖细胞的募集和迁移。作者对激肽释放酶-激肽系统在缺血损伤后血管新生中的作用研究进展作一综述。

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