血清IL-6、IL-8在足月胎膜早破亚临床感染诊断中的临床意义-东南大学学报医学版

血清IL-6、IL-8在足月胎膜早破亚临床感染诊断中的临床意义

单位：南京医科大学附属南京医院, 南京市第一医院妇产科, 江苏南京 210006

分类号：R714.43

出版年·卷·期（页码）：2012·31·第六期（751-756）

摘要：

目的:观察血清白介素-6(IL-6)及白介素-8(IL-8)在胎膜早破亚临床感染孕妇中的变化,探讨其在胎膜早破及绒毛膜羊膜炎早期诊断中的临床意义。方法:选择100例胎膜早破孕妇为实验组,根据破膜时间进一步分两个亚组,A组破膜时间<12 h,B组破膜时间≥12 h;选择同期50例年龄、孕周与实验组相近的择期剖宫产孕妇作为对照组;所有孕妇均无临床感染征象。用酶联免疫吸附试验(ELISA)测定各组孕妇血清IL-6、IL-8水平,并于分娩时取胎盘送病理学检查。结果:(1) 实验组孕妇血清中IL-6、IL-8水平明显高于对照组,且B组血清IL-6、IL-8水平及绒毛膜羊膜炎发生率高于A组;(2)病理学检查显示绒毛膜羊膜炎的孕妇血清中IL-6、IL-8水平高于无绒毛膜羊膜炎者。结论:检测胎膜早破孕妇血中IL-6、IL-8水平对胎膜早破并亚临床绒毛膜羊膜炎的早期诊断具有重要意义。

Objective: To observe the expression of serum IL-6,IL-8 in pregnant woman with premature rupture of membranes(PROM) and to approach the relationship between serum IL-6,IL-8 and chorioamnionitis. Methods: One hundred cases of gravidas diagnosed as PROM without any clinical signs were selected as experimental group and they were divided into two groups:group A (rupture of membranes less than 12 h) and group B(rupture of membranes no less than 12 h). Fifty cases of normal pregnant women who had similar gestational age were selected as control group. The serum levels of IL-6 and IL-8 were detected by enzyme-linked immunosorbent assay (ELISA),and all the placenta were sened for pathological examination. Results: (1)The serum levels of IL-6,IL-8 in experimental group were significantly higher than those in control group. The incidence of chorioamnionitis in experimental group was higher than that in control group,the longer PROM time,the higher rates. (2) The levers of serum IL-6,IL-8 in the women with histological chorioamnionitis were significantly higher than women without histological chorioamnionitis. Conclusion: The serum levels of IL-6,IL-8 in women with PROM are associated with the onset of subclinical chorioamnionitis,and their levels are valuable to diagnose the early stage of PROM with chorioamnionitis.

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