Objective: To evaluate the clinical effects of hydrogel dressing Aquacel-Ag in treatment of superficial Ⅱ burns. Methods: Using random select method, 30 patients whose burn areas covered with hydrogel dressing Aquacel-Ag(hydrogel dressing Aquacel-Ag group) and 30 patients whose burn areas coped with SD-Ag(SD-Ag group) were picked as research objects. The healing time, the frequency of dressing changes and the dressing pain score were compared between the two groups. Meanwhile, the wound secretion was taken for bacteria culturing, blood routine test, blood biochemical test and adverse effect were closely monitered during the treatment. Results: Compared with SD-Ag group, hydrogel dressing Aquacel-Ag group exhibited a significantly shorter healing time (P<0.05);moreover, hydrogel dressing Aquacel-Ag also resulted in significantly lessen dressing changes (P<0.01) and reduced dressing pain score(P<0.05). However, the outcomes of bacterial culture were not significantly different between the two groups (P>0.05). There was no direct relationship between the laboratory abnormalities and the therapeutic measures, and most patients had no uncomfortable chief complaint. Conclusions: Hydrogel dressing Aquacel-Ag could shorten the healing time, decrease frequency of dressing change and reduce dressing pain score for superficial Ⅱ burns. It has an antimicrobial property similar to SD-Ag for superficial Ⅱ burns and shows no noticeable adverse effect. So, it is worth clinical further application.